Association between Corneal Biomechanical Properties with Ocular Response Analyzer and Also CorvisST Tonometry, and Glaucomatous Visual Field Severity.
Association between Corneal Biomechanical Properties with Ocular Response Analyzer and Also CorvisST Tonometry, and Glaucomatous Visual Field Severity.
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DOI：
10.1167/tvst.6.3.18
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发表时间：
2017-06
影响因子：
3
通讯作者：
Asaoka R
中科院分区：
文献类型：
--
作者：
Hirasawa K;Matsuura M;Murata H;Nakakura S;Nakao Y;Kiuchi Y;Asaoka R
研究眼反应分析仪（ORA）和CorvisST（CST）眼压计测量的角膜生物力学特性与昏迷性视野（VF）严重程度之间的相关性。在180天内进行Humphrey Field Analyzer 30-2或24-2 SITA标准、ORA和CST的91例原发性开角型青光眼患者的146只眼被纳入这项多中心、观察性横断面研究。ORA参数之间的关联（角膜滞后[CH]和角膜阻力因子[CRF]），CST参数（A1、A2时间、A1、A2长度、A1、A2速度、A1、A2变形幅度、最大变形幅度、最大变形时间、峰值距离、半径）等基本参数（年龄，Goldmann压平眼压计眼压，中央角膜厚度，和轴长）对平均总偏差（mTD）进行了分析，使用线性混合模型和模型选择校正赤池信息标准（AICc）。VF严重程度的最佳模型包括ORA的CH以及许多CST参数，包括A1长度、A2时间、半径和最高的AICc变形幅度（AICc：971.7）。该模型比不含CST参数的最佳模型更准确地描述视野严重程度的可能性为99.98%。青光眼VF的严重程度最好用ORA和CST参数来描述。在CST测量中，角膜在最大变形时出现尖锐和深压痕、第一次压平时出现宽压痕以及第二次压平早期的眼睛更有可能显示出晚期VF严重程度。CorvisST眼压测量参数与青光眼患者VF严重程度相关。
To investigate the association between corneal biomechanical properties measured with the Ocular Response Analyzer (ORA) and also CorvisST (CST) tonometry, and glaucomatous visual field (VF) severity. One hundred forty-six eyes of 91 patients with primary open-angle glaucoma who performed Humphrey Field Analyzer 30-2 or 24-2 SITA-Standard, ORA, and CST within 180 days were included in this multicentral, observational cross-sectional study. The association between ORA parameters (corneal hysteresis [CH] and corneal resistant factor [CRF]), CST parameters (A1 and A2 time, A1 and A2 length, A1 and A2 velocity, A1 and A2 deformation amplitude, highest deformation amplitude, highest concavity time, peak distance, and radius), and other basic parameters (age, intraocular pressure with Goldmann applanation tonometry, central corneal thickness, and axial length) against mean total deviation (mTD) were analyzed using a linear mixed-model and model selection with corrected Akaike Information Criterion (AICc). The optimal model of VF severity included ORA's CH as well as a number of CST parameters, including A1 length, A2 time, radius, and highest concavity deformation amplitude (AICc: 971.7). The possibility this model describes visual field severity more accurately than the optimal model without CST parameters was 99.98%. Glaucomatous VF severity was best described by both ORA and CST parameters. Eyes with corneas that experience sharp and deep indentation at the maximum deformation, wide indentation at the first applanation, and early second applanation in the CST measurement are more likely to show advanced VF severity. CorvisST tonometry parameters are related to VF severity in glaucoma patients.