Interactions between Nod-Like Receptors and Intestinal Bacteria.
Interactions between Nod-Like Receptors and Intestinal Bacteria.
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DOI：
10.3389/fimmu.2013.00462
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发表时间：
2013-12-17
影响因子：
7.3
通讯作者：
Flavell RA
中科院分区：
文献类型：
--
作者：
de Zoete MR;Flavell RA
核苷酸寡聚化结构域（Nod）样受体（NLR）是介导半胱天冬酶-1活化和促炎细胞因子IL-1β和IL-18的后续加工和分泌以及称为焦亡的炎性细胞死亡的胞质传感器。虽然许多细菌已显示在体外条件下激活一种或多种NLR，但在致病性和寄生性的定殖过程中NLR激活的确切影响尚不清楚。在这篇综述中，我们将重点介绍肠道NLR在常见胃肠道细菌病原体感染的各个阶段的作用，以及NLR在控制和塑造微生物群中的功能。
Nucleotide oligomerization domain (Nod)-like Receptors (NLRs) are cytosolic sensors that mediate the activation of Caspase-1 and the subsequent processing and secretion of the pro-inflammatory cytokines IL-1β and IL-18, as well as an inflammatory cell death termed pyroptosis. While a multitude of bacteria have been shown to activate one or more NLRs under in vitro conditions, the exact impact of NLR activation during the course of colonization, both of pathogenic and commensal nature, is less understood. In this review, we will focus on the role of intestinal NLRs during the various stages of infection with common gastrointestinal bacterial pathogens, as well as NLR function in controlling and shaping the microbiota.