Percutaneous penetration following use of hair dyes.
Percutaneous penetration following use of hair dyes.
复制标题
使用染发剂后经皮渗透。
作者：
R. S. Yare;M. Garcia
致编辑Maibach等人1在《档案》中报道，8名受试者中有4名在用两种市售半永久性染发剂之一染发后1 - 4天采集尿样，进行薄层色谱（TLC）分析，发现有紫色斑点。该斑点（未鉴别）与两种染料制剂相同，在受试者尿样的对照TLC和两种染发剂的TLC中均未检出。作者得出结论，“这些染发剂很可能并不罕见地渗透皮肤，”紫色斑点很可能是代谢产物。我们在14名受试者中的13名受试者的尿液标本中发现了相同的紫色斑点，这些受试者根据Maibach等人的程序进行了治疗，即，将浓缩物乙醚萃取至pH 1，然后将浓缩物乙醚萃取至pH 1。
To the Editor.— Maibach et al1reported in theArchivesthat thin-layer chromatography (TLC) of urine samples from four of eight subjects, which were taken one to four days after they had dyed their hair with one of two commercially distributed, semipermanent hair dyes, disclosed a purple spot. The spot, which was unidentified, was the same with both dye preparations and was neither detected in control TLC of urine samples from the subjects nor in TLC of either hair dye. The authors concluded that "It is likely that these hair dyes not uncommonly penetrate the skin," and that the purple spot was most likely a metabolite. We found the same purple spot in urine specimens from 13 of 14 subjects who had been treated according to the procedure of Maibach et al, ie, ether extraction of concentrates that were adjusted to pH 1, followed by ether extraction of the