EFFECTIVE STIMULATION DISTANCE FOR CURRENT FROM MACROELECTRODES
EFFECTIVE STIMULATION DISTANCE FOR CURRENT FROM MACROELECTRODES
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DOI：
10.1016/0014-4886(86)90126-3
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发表时间：
1986-04-01
影响因子：
5.3
通讯作者：
MANN, MD
中科院分区：
文献类型：
--
作者：
FOLLETT, KA;MANN, MD
使用锥体束轴突的逆向反应作为激发指标来测量来自大电极的刺激电流的有效传播。单极和同心双极电极配置均在刺激距离高达 7 毫米的情况下进行了测试。单极电极的有效刺激距离更大，特别是在电流强度更大的情况下，但两种配置之间的差异通常很小，并且这种趋势发生了逆转。使用大轴突和小轴突进行的有效刺激距离的估计之间没有统计学上的显着差异。使用双极和单极刺激时，电流-距离曲线的形状近似为抛物线。 0.5 至 1.0 mA 的电流强度会将单极电极的有效电流限制在半径 2 毫米的球体内，但不会刺激该区域内的所有元素。即使在像锥体束一样均匀的大脑区域中，有效刺激距离的平均值仍然存在很大的变异性。据推测，在异质性更强的地区，变异性会更大。
Effective spread of stimulating current from macroelectrodes was measured using antidromic responses of axons of the pyramidal tract as an indicator of excitation. Both monopolar and concentric bipolar electrode configurations were tested with stimulating distances as large as 7 mm. The effective stimulation distance was greater from monopolar electrodes especially at greater current strengths, but differences between the two configurations were frequently small and reversals of this trend occurred. There was no statistically significant difference between the estimates of effective stimulation distance made using large and small axons. The shape of current-distance curves was approximately parabolic using both bipolar and monopolar stimulation. A current strength of 0.5 to 1.0 mA will confine effective current from a monopolar electrode to a sphere of 2-mm radius, but will not stimulate all elements within that area. Even in a brain area as homogeneous as the pyramidal tract, there is still a great deal of variability from mean values in effective stimulation distance. Presumably, the variability would be even greater in more heterogeneous regions.