Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women
Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women
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DOI：
10.1194/jlr.p000935
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发表时间：
2010-05-01
影响因子：
6.5
通讯作者：
Goldberg, Andrew P.
中科院分区：
文献类型：
--
作者：
Fried, Susan K.;Tittelbach, Thomas;Goldberg, Andrew P.
高脂肪酸（FA）通量与全身胰岛素抵抗相关，非洲裔美国人（AA）女性往往更胰岛素抵抗。我们评估了从超重、绝经后AA和白人（C）女性的腹部（Abd）和臀部（Glt）皮下（sc）脂肪组织分离的脂肪细胞中胰岛素抗脂解作用的可能贮库和种族差异。AA女性的体脂百分比、空腹胰岛素、内脏脂肪过多和脂肪细胞大小较高。每单位脂肪细胞表面积的去抑制脂解（腺苷脱氨酶的存在）在Abd和Glt以及AA和C中相似。然而，即使在调整了脂肪百分比和内脏脂肪面积后，AA的Abd女性的“基础”[次最大苯基异丙基腺苷（PIA）抑制]和胰岛素抑制的脂解率仍高于C女性。AA患者PIA和胰岛素抑制脂解率的种族差异与其高胰岛素血症相关，但AA种族与空腹胰岛素无关，与对次最大胰岛素浓度的反应性（抑制百分比）较低相关，尽管敏感性（ED 50）不受影响。总的来说，这些数据与Abd脂肪细胞对抗脂肪分解效应物的反应性降低可能有助于更高的FA可用性，从而导致胰岛素抵抗的种族差异的假设一致。弗里德，S。K.，T. Tittelbach，J.布卢门塔尔，U.斯里尼瓦桑湖Robey，J. Yi，S.汗角Hollender，A. S. Ryan和A. P·戈德堡非裔美国人与白人绝经后妇女脂肪细胞对胰岛素抗脂解作用的抵抗J. Lipid Res. 2010. 51：1193-1200。
High fatty acid ( FA) flux is associated with systemic insulin resistance, and African-American ( AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated from abdominal (Abd) and gluteal (Glt) subcutaneous (sc) adipose tissue of overweight, postmenopausal AA and Caucasian ( C) women. Percent body fat, fasting insulin, visceral adiposity, and adipocyte size was higher in AA women. Disinhibited lipolysis ( presence of adenosine deaminase) per unit adipocyte surface area was similar in Abd and Glt and in AA and C. However, rates of 'basal' [submaximal phenylisopropyl adenosine ( PIA) suppressed] and insulin-suppressed lipolysis were higher in Abd of AA compared with C women even after adjustment for percent fat and visceral fat area. The race difference in rates of PIA- and insulin-suppressed lipolysis in AA were correlated with their hyperinsulinemia, but AA race, independent of fasting insulin, was associated with lower responsiveness ( percent suppression) to submaximal insulin concentrations, although sensitivity (ED50) was not affected. Overall, these data are consistent with the hypothesis that decreased responsiveness of Abd adipocytes to antilipolytic effectors may contribute to higher FA availability and thereby to racial differences in insulin resistance.-Fried, S. K., T. Tittelbach, J. Blumenthal, U. Sreenivasan, L. Robey, J. Yi, S. Khan, C. Hollender, A. S. Ryan, and A. P. Goldberg. Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women. J. Lipid Res. 2010. 51: 1193-1200.