Depression and possible cancer risk due to oxidative DNA damage
Depression and possible cancer risk due to oxidative DNA damage
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DOI：
10.1016/j.jpsychires.2005.01.009
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发表时间：
2005-11-01
影响因子：
4.8
通讯作者：
Kasai, H
中科院分区：
文献类型：
--
作者：
Irie, M;Miyata, M;Kasai, H
抑郁症和癌症之间的潜在联系是一个尚未解决的重要问题。为了阐明这一点，我们比较了30名抑郁症患者和60名年龄和性别匹配的健康对照者外周血白细胞中与癌症相关的氧化性DNA损伤8-羟基脱氧鸟苷（8-OH-dG），并检查了8-OH-dG相关因素。采用流行病学研究中心抑郁量表（CES-D）和心境状态量表（POMS）评定抑郁程度。患者的8-OH-dG水平显著高于对照组。抑郁症患者，尤其是女性患者，CES-D评分与8-OH-dG水平呈显著正相关。多元回归分析表明，无论是患者或对照组是一个显着的预测8-OH-dG水平在男性和总的受试者，是CES-D评分或抑郁-拒绝评分的POMS在女性受试者。这项研究表明，临床抑郁症是一个危险因素，癌症的启动，鉴于氧化DNA损伤。(c)2005爱思唯尔有限公司保留所有权利。
The potential link between depression and cancer is an important unsolved question. To clarify this, we compared a cancer-related oxidative DNA damage, 8-hydroxydeoxyguano sine (8-OH-dG), in peripheral leukocytes between 30 patients with depression and 60 age- and gender-matched healthy controls, and examined the 8-OH-dG-related factors. The degree of depression was assessed by the scores of the Center for Epidemiologic Studies Depression scale (CES-D) and the Profile of Mood States (POMS). The patients showed significantly higher 8-OH-dG levels than the controls. There was a significant positive correlation between the CES-D scores and the 8-OH-dG levels in depressive, particularly female, patients. Multiple regression analysis indicated that whether the subjects were patients or controls was a significant predictor of the 8-OH-dG levels in male and total subjects, as was the CES-D score or the Depression-Rejection score of the POMS in female subjects. This study suggests that clinical depression is a risk factor for cancer initiation in view of oxidative DNA damage. (c) 2005 Elsevier Ltd. All rights reserved.