Verrucous Hyperplasia of the Great Toe: A Case and a Review of the Literature
Verrucous Hyperplasia of the Great Toe: A Case and a Review of the Literature
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大脚趾疣状增生：一例及文献复习
DOI：
10.1111/j.1524-4725.2004.30070.x
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发表时间：
2004
影响因子：
2.4
通讯作者：
Jin Lee
中科院分区：
文献类型：
--
作者：
N. Scheinfeld;Thomas Yu;Jin Lee
背景疣状增生是一种增生性疾病，表现为残肢截肢部位合并的疣状丘疹。经常被忽视，它可以与疣状癌混淆。因此，它是皮肤科医生关注的问题。目的报告1例疣状增生并复习文献。方法：我们报告一位62岁的糖尿病患者，在她的前三个右脚趾截肢部位出现了一个疣状结节。尽管多次手术切除和皮肤移植，疣状结节重新发展。活检显示指状表皮增生，薄毛乳头内毛细血管扩张迂曲，无侵袭性特征、核分裂像或棘层向下生长。聚合酶链反应未检出人乳头瘤病毒。结果诊断为截肢后疣状增生。结论疣状增生不应与疣状癌或疣混淆。此外，因为它在切除后复发，所以不需要手术;相反，需要加压治疗。
BACKGROUND Verrucous hyperplasia is a hyperplastic disease that manifests as coalescent warty papules at stump amputation sites. Often overlooked, it can be confused with verrucous carcinoma. As such, it is of concern for dermatologic surgeons. OBJECTIVE To present a patient with verrucous hyperplasia and review its literature. METHODS We report a 62-year-old diabetic patient with a verrucous nodule that arose at the amputation site of her first three right toes. Despite repeated surgical removals and skin graftings, the verrucous nodule redeveloped. A biopsy revealed digitate epidermal hyperplasia with dilated tortuous capillaries in thin dermal papilla without invasive features, mitotic figures, or acanthotic downgrowth. Polymerase chain reaction did not detect human papilloma virus. RESULTS Verrucous hyperplasia secondary to amputation was diagnosed. CONCLUSION Verrucous hyperplasia occurs should not be confused with verrucous carcinoma or warts. Moreover, because it recurs after removal, surgery is not indicated; rather, compression therapy is indicated.