Shortened telomere length in white blood cells of patients with IDDM
Shortened telomere length in white blood cells of patients with IDDM
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DOI：
10.2337/diabetes.47.3.482
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发表时间：
1998-03-01
期刊：
影响因子：
7.7
通讯作者：
Aviv, A
中科院分区：
文献类型：
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作者：
Jeanclos, E;Krolewski, A;Aviv, A
IDDM是一种多基因的自身免疫性疾病，其中白色细胞（WBC）参与胰腺β细胞的破坏，这些细胞在IDDM中的异常行为的机制尚未完全了解。通过测量来自IDDM患者的WBCs的平均端粒长度，我们验证了端粒可能在IDDM中起作用的概念。我们检测了234例白色男性（包括54例IDDM、74例NIDDM和106例对照）白细胞DNA末端限制性片段（TRF）的长度。经年龄校正后，IDDM患者白细胞TRP长度显著短于非糖尿病对照（平均± SE：8.6 ± 0.1vs，9.2 ± 0.1，P = 0.002）。NIDDM患者与非糖尿病患者白细胞TRF长度无显著性差异。IDDM患者WBC的TRF长度缩短可能反映了在IDDM发病机制中起作用的WBC亚群的TRF长度显著减少。
IDDM is a polygenic and autoimmune disorder in which subsets of white blood cells (WBCs) are engaged in the destruction of beta-cells of the pancreas, The mechanisms that account for the abnormal behavior of these cells in IDDM are not fully understood, By measuring the mean length of telomeres of WBCs from patients with IDDM, we tested the concept that telomeres might play a role in IDDM. We examined the lengths of the terminal restriction fragments (TRFs) of DNA of WBCs from 234 white men comprising 54 patients with IDDM, 74 patients with NIDDM, and 106 control subjects, When adjusted for age, the TRP length from WBCs of patients with IDDM was significantly shorter than that of nondiabetic control subjects (mean +/- SE: 8.6 +/- 0.1 vs, 9.2 +/- 0.1, P = 0.002), No significant difference was observed between the TRF length from WBCs of patients with NIDDM versus nondiabetic subjects, Neither the duration nor the complications of IDDM (i,e,, nephropathy and hypertension) had apr effect on the TRF length of WBCs from patients with IDDM. The shortened TRF length of WBCs of patients with IDDM likely reflects a marked reduction in the TRF length of subsets of WBCs that play a role in the pathogenesis of IDDM.