Sensitivity and specificity of mass screening for gastric cancer using the measurement of serum pepsinogens
Sensitivity and specificity of mass screening for gastric cancer using the measurement of serum pepsinogens
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DOI：
10.1111/j.1349-7006.1995.tb03317.x
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发表时间：
1995-12-01
期刊：
影响因子：
--
通讯作者：
Kodama, Y
中科院分区：
文献类型：
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作者：
Hattori, Y;Tashiro, H;Kodama, Y
本研究的目的是评估使用血清胃蛋白酶原（PG测试）对胃癌进行大规模筛查的有效性，研究对象为4876名年龄在40至61岁之间的工人，在健康检查时获取血清，同时测量血清胃蛋白酶原水平（PG I和PG II）。 PG I < 50 ng/ml 和 PG I/PG II 比值 < 3.0 作为 PG 测试阳性结果的标准。 PG检测阳性受试者原则上通过内窥镜检查进行检查。此外，对所有受试者进行为期一年的随访，检查是否发生胃癌，其中911例（18.7%）PG检测呈阳性，其中650例（71.4%）进行进一步检查，结果发现11例胃癌。 PG检查后一年内的随访期间诊断出7例胃癌。 7 例癌症病例中有 6 例 PG 检测呈阴性，当将筛查后一年的随访结果定义为金标准时，PG 检测的敏感性和特异性估计分别为 66.7% 和 81.5%。作者得出结论，如果选择阳性检测的最佳标准，PG 检测作为大众筛查方法的有效性可能与 X 射线筛查相当。
The aim of this study was to estimate the validity of mass screening for gastric cancer using serum pepsinogens (PG test), The study subjects were 4876 workers aged from 40 to 61 years old, Sera were obtained at the time of the health checkup and serum pepsinogen levels (PG I and PG II) were measured at the same time. PG I < 50 ng/ml and PG I/PG II ratio < 3.0 were adopted as the criteria for a positive result for the PG test. PG test-positive subjects were examined, in principle, by endoscopy. Furthermore, all the subjects were followed up for a year to check for occurrence of gastric cancer, Among the total subjects, 911 (18.7%) were positive for the PG test and 650 (71.4%) among the positive subjects underwent further examinations, which revealed 11 cases of gastric cancer. Seven gastric cancer cases were diagnosed during the follow-up period within one year after the PG test. Six out of the 7 cancer cases had been negative in the PG test, When the results of one year's follow-up from the time of screening were defined as the gold standard, the sensitivity and specificity of the PG test were estimated at 66.7% and 81.5%, respectively, The authors conclude that the validity of the PG test as a mass screening method may be comparable to that of X-ray screening, if optimum criteria of a positive test are selected.