Involvement of rodent prefrontal cortex subregions in strategy switching.
Involvement of rodent prefrontal cortex subregions in strategy switching.
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啮齿类动物前额皮质亚区参与策略转换。
DOI：
10.1037//0735-7044.113.1.32
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发表时间：
1999
影响因子：
1.9
通讯作者：
Kesner,RP
中科院分区：
文献类型：
--
作者：
Ragozzino,ME;Wilcox,C;Raso,M;Kesner,RP
本研究考察了前边缘-边缘下区或前扣带背区失活是否会损害奶酪板任务中的策略转换。在针对边缘前-边缘下区或前扣带背区植入套管后，所有大鼠都接受了空间和视觉提示版本的任务测试。一些老鼠首先接受了空间版本，然后是视觉版本。其他老鼠的实验过程则相反。将2%的丁卡因输注到边缘前-边缘下或前扣带背区，不会损害空间或视觉线索的获取。然而，当大鼠从一个版本切换到另一个版本时，边缘前-边缘下区域的失活，而不是背前扣带区域，会损害学习能力。这些发现表明，边缘前区和边缘下区参与了转向新的行为指导策略的过程。（PsycINFO数据库记录(c) 2016 APA，版权所有）
The present study examined whether inactivation of the prelimbic–infralimbic areas or the dorsal anterior cingulate area impairs strategy switching in the cheeseboard task. After implantation of a cannula aimed at either the prelimbic–infralimbic or dorsal anterior cingulate areas, all rats were tested in a spatial and a visual-cued version of the task. Some of the rats received the spatial version first, followed by the visual-cued version. The procedure for the other rats was reversed. Infusions of 2% tetracaine into the prelimbic–infralimbic or dorsal anterior cingulate areas did not impair acquisition of the spatial or visual-cued versions. However, inactivation of the prelimbic–infralimbic areas, but not the dorsal anterior cingulate area, impaired learning when rats were switched from one version to the other. These findings suggest that the prelimbic–infralimbic areas are involved in switching to new behavior-guiding strategies.(PsycINFO Database Record (c) 2016 APA, all rights reserved)