Dietary β-hydroxy-β-methylbutyrate supplementation influences performance differently after immunization in broiler chickens
Dietary β-hydroxy-β-methylbutyrate supplementation influences performance differently after immunization in broiler chickens
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DOI：
10.1111/j.1439-0396.2008.00833.x
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发表时间：
2009-08-01
影响因子：
2.7
通讯作者：
Goddeeris, B. M.
中科院分区：
文献类型：
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作者：
Buyse, J.;Swennen, Q.;Goddeeris, B. M.
饮食中添加亮氨酸代谢产物β-羟基-β-甲基丁酸盐（HMB）促进各种物种的生长。此外，HMB被描述为增强可能与代谢成本相关的免疫应答。我们进一步阐述了HMB在生长，代谢和免疫的肉型鸡使用以下参数的作用：动物技术性能，血液化学和免疫后的人血清白蛋白（HSA）/弗氏（在）完全佐剂组合的特定免疫应答。鸡接受未补充或补充有300 mg HMB/kg饲料的市售饲料。补充β-羟基-β-甲基丁酸盐的鸡在2周龄时明显较重，但这种差异在以后的年龄减弱。与未添加HMB的对照组相比，添加HMB的鸡的累积饲料转化率显著降低。两种饮食处理之间的血液化学无差异。免疫后，HMB在免疫后第1天显著减弱了急性期蛋白反应，与未补充的对应物相比。免疫后第7天，免疫攻击的HMB补充鸡的体重增长显着抑制，但其特异性抗HSA IgG反应显着增强相比，其免疫攻击的未补充的同行。这些现象的潜在机制和信号通路需要阐明。尽管如此，我们可以得出结论，HMB在正常情况下对性能有益。另一方面，HMB在免疫攻击后刺激免疫应答，但以降低生长为代价。
P>Dietary addition of the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) promotes growth in various species. In addition, HMB is described to enhance immune responses which might be associated with metabolic costs. We elaborated further on the role of HMB in growth, metabolism and immunity of meat-type chickens using the following parameters: zootechnical performance, blood chemistry and a specific immune responses after immunization with a human serum albumin (HSA)/Freund's (in) complete adjuvant combination. The chickens received commercial feeds either unsupplemented or supplemented with 300 mg HMB/kg feed. beta-hydroxy-beta-methylbutyrate-supplemented chickens were significantly heavier at 2 weeks of age but this difference was attenuated at later ages. Compared with their unsupplemented controls, cumulative feed conversion was significantly lower in HMB-supplemented chickens. There were no differences in blood chemistry between both dietary treatments. After immunization, HMB significantly attenuated the acute phase protein response at day 1 of post-immunization compared with that of their unsupplemented counterparts. After day 7 post-immunization, body weight gain of the immuno-challenged HMB-supplemented chickens was significantly depressed, but their specific anti-HSA IgG response was significantly enhanced compared with that of their immuno-challenged unsupplemented counterparts. The underlying mechanisms and signalling pathways for these phenomena need to be elucidated. Nevertheless, we are able to conclude that HMB is beneficial for performance under normal circumstances. On the other hand, HMB stimulates the immune response after an immunological challenge, though at the cost of reduced growth.