Subclinical infection with avian influenza A (H5N1) virus in cats
Subclinical infection with avian influenza A (H5N1) virus in cats
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DOI：
10.3201/eid1302.060608
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发表时间：
2007-02-01
影响因子：
11.8
通讯作者：
Thalhammer, Johann G.
中科院分区：
文献类型：
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作者：
Leschnik, Michael;Weikel, Joachim;Thalhammer, Johann G.
H5N1亚型禽流感病毒通过与感染禽类密切接触传播给家猫。从一组194只动物（与受感染的天鹅接触后第8天）的40只随机抽样猫中的3只的咽拭子中检测到病毒特异性核酸。将所有猫转移至检疫站，并监测临床体征、病毒脱落和抗体产生，直至第50天。尽管不熟悉的处理，社会压力，以及其他病毒和非病毒病原体的存在，导致疾病和健康状况不佳，并损害免疫系统，流感的临床体征没有在任何猫发展。没有证据表明H5N1病毒会水平传播给其他猫，因为只有两只猫产生了H5N1病毒抗体。
Avian influenza A virus subtype H5N1 was transmitted to domestic cats by close contact with infected birds. Virus-specific nucleic acids were detected in pharyngeal swabs from 3 of 40 randomly sampled cats from a group of 194 animals (day 8 after contact with an infected swan). All cats were transferred to a quarantine station and monitored for clinical signs, virus shedding, and antibody production until day 50. Despite unfamiliar handling, social distress, and the presence of other viral and nonviral pathogens that caused illness and poor health and compromised the immune systems, clinical signs of influenza did not develop in any of the cats. There was no evidence of horizontal transmission to other cats because antibodies against H5N1 virus developed in only 2 cats.