Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance.
Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance.
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DOI：
10.1016/s1461-5347(00)00269-8
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发表时间：
2000-06-01
期刊：
影响因子：
--
通讯作者：
Peppas
中科院分区：
文献类型：
--
作者：
Colombo;Bettini;Peppas
大多数口服药物递送系统 (DDS) 都是基于基质的。可溶胀基质是通过压缩亲水性聚合物和药物的粉末混合物制备的整体系统。他们的成功与成熟的压片制造技术有关。可膨胀基质 DDS 必须与真正的膨胀控制递送系统区分开来。本综述重点关注作为受控 DDS 的亲水性可膨胀骨架片。描述了凝胶层行为、前沿移动和释放，以显示释放动力学对系统溶胀行为的依赖性。还考虑了基质系统的体内行为。
The majority of oral drug delivery systems (DDS) are matrix-based. Swellable matrices are monolithic systems prepared by compression of a powdered mixture of a hydrophilic polymer and a drug. Their success is linked to the established tabletting technology of manufacturing. Swellable matrix DDS must be differentiated from true swelling-controlled delivery systems. This review focuses on hydrophilic swellable matrix tablets as controlled DDS. Gel-layer behaviour, front movement and release are described to show the dependence of the release kinetics on the swelling behaviour of the system. In vivo behaviour of matrix systems is also considered.