Assessing measles vaccine failure in Tianjin, China.
Assessing measles vaccine failure in Tianjin, China.
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评估中国天津的麻疹疫苗失败情况。
DOI：
10.1016/j.vaccine.2019.05.005
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发表时间：
2019
期刊：
影响因子：
5.5
通讯作者：
Boulton,MatthewL
中科院分区：
文献类型：
--
作者：
Masters,NinaB;Wagner,AbramL;Ding,Yaxing;Zhang,Ying;Boulton,MatthewL
尽管全球麻疹疫苗接种覆盖率不断提高，但近年来消除麻疹的进展有所放缓。在中国，儿童在8个月、18-24个月时接种麻疹疫苗（MCV），一些城市地区在4-6岁时接种第三剂。然而，在中国天津，大量麻疹病例发生在接受多次MCV接种的个体中。本研究描述了8个月~ 19岁麻疹病例的疫苗接种史。数据来自天津市可报告疾病监测系统中的麻疹病例（2009-2013年）和病例对照研究（2011-2015年）。监测数据集中29%的人和病例系列中54.4%的人至少接受了一剂MCV。接种疫苗后至诊断的最短和中位时间显示，接种增量剂量疫苗后的时间延长。天津市相当多的麻疹病例发生在接种疫苗的儿童中，需要进一步研究以了解疫苗失败的原因。
Despite increasing global measles vaccination coverage, progress toward measles elimination has slowed in recent years. In China, children receive a measles-containing vaccine (MCV) at 8 months, 18–24 months, and some urban areas offer a third dose at age 4–6 years. However, substantial measles cases in Tianjin, China, occur among individuals who have received multiple MCV doses. This study describes the vaccination history of measles cases 8 months – 19 years old. Data came from measles cases in Tianjin’s reportable disease surveillance system (2009–2013), and from a case control study (2011–2015). Twenty-nine percent of those in the surveillance dataset and 54.4% of those in the case series received at least one dose of MCV. The minimum and median time-to-diagnosis since vaccination revealed an increase in time since vaccination for incremental doses. Considerable measles cases in Tianjin occur in vaccinated children, and further research is needed to understand the reasons for vaccine failure.