Mechanisms and origins of RNA editing.
Mechanisms and origins of RNA editing.
复制标题
RNA 编辑的机制和起源。
DOI：
10.1016/s0959-437x(05)80060-7
复制
发表时间：
1994
影响因子：
4
通讯作者：
Hajduk,SL
中科院分区：
文献类型：
--
作者：
Adler,BK;Hajduk,SL
RNA编辑是一个重要的转录后过程，已经在越来越多的真核生物中被发现。在过去的一年里，在研究RNA编辑机制的体外系统的开发方面取得了进展。对锥虫线粒体中核苷酸插入/缺失编辑的分析揭示了体内和体外存在推定的编辑中间体。哺乳动物载脂蛋白B mRNA的体外编辑系统的发展，允许阐明这种形式的RNA编辑的序列要求和生化机制。此外，最近的工作已经强调了RNA的多样性，其结构和功能被翻译后编辑反应改变。
RNA editing is an essential post-transcriptional process that has been identified in an increasing number of eukaryotic organisms. In the past year, progress has been made in the development ofin vitrosystems to study the mechanism of RNA editing. Analysis of nucleotide insertion/deletion editing in trypanosome mitochondria has revealed the existence of putative editing intermediatesin vivoandin vitro. The development of anin vitroediting system for mammalian apolipoprotein B mRNA has allowed the elucidation of both the sequence requirements and the biochemical mechanism of this form of RNA editing. In addition, recent work has underscored the diversity of RNAs whose structure and function are altered by post-translational editing reactions.