Apoptosis-induced anti-tumor effect of Curcuma kwangsiensis polysaccharides against human nasopharyngeal carcinoma cells.
Apoptosis-induced anti-tumor effect of Curcuma kwangsiensis polysaccharides against human nasopharyngeal carcinoma cells.
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DOI：
10.1016/j.carbpol.2012.03.064
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发表时间：
2012-08
影响因子：
11.2
通讯作者：
Jian-hong Zeng;P. Dai;Lingyun Ren;Boram Song;Xu Chen;Xiaohua Wang;Jianhong Wang;Tiecheng Zhang;Wei-Guo Zhu
中科院分区：
文献类型：
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作者：
Jian-hong Zeng;P. Dai;Lingyun Ren;Boram Song;Xu Chen;Xiaohua Wang;Jianhong Wang;Tiecheng Zhang;Wei-Guo Zhu
本研究旨在探讨姜黄多糖对人鼻咽癌细胞系CNE-2细胞活力的影响，并探讨其可能的作用机制。用不同浓度的光参多糖处理CNE-2细胞，观察其增殖、凋亡及凋亡相关调节因子p53和Bcl-2的蛋白表达情况。结果表明，川芎多糖能显著抑制CNE-2细胞的增殖，其机制可能是通过降低Bcl-2的表达，促进p53的表达而诱导细胞凋亡。因此，本研究表明，广山参多糖可开发为治疗鼻咽癌的潜在药物。
This study aimed to investigate the effect of Curcuma kwangsiensis polysaccharides on the viability of human nasopharyngeal carcinoma cell line CNE-2 cells, and explore the possible mechanisms. CNE-2 cells were treated with various concentrations of C. kwangsiensis polysaccharides, then the proliferation, apoptosis and the protein expression of apoptosis-related regulators p53 and Bcl-2 were assessed. The results demonstrated that C. kwangsiensis polysaccharides can significantly inhibit the proliferation of CNE-2 cells, which was possibly through the induction of apoptosis mediated by attenuating Bcl-2 expression and promoting p53 expression. The present study therefore indicates that C. kwangsiensis polysaccharides could be developed into potential drugs for nasopharyngeal carcinoma treatment.