Preparation of nanoparticles by continuous-flow microfluidics
Preparation of nanoparticles by continuous-flow microfluidics
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DOI：
10.1007/s11051-007-9340-5
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发表时间：
2008-08-01
影响因子：
2.5
通讯作者：
Gaitan, Michael
中科院分区：
文献类型：
--
作者：
Jahn, Andreas;Reiner, Joseph E.;Gaitan, Michael
我们回顾了用微流体方法生产的各种微颗粒和纳米颗粒配方。已经报道了各种各样的方法来产生微尺度和纳米尺度的粒子。在这里，我们强调使用微流体，特别是在连续流动模式下运行的微流体系统，从而允许连续生成所需的颗粒配方。半导体量子点，金属胶体，乳剂和脂质体的产生被考虑。为了强调连续流微流控方法在纳米颗粒生成方面的潜在优势，我们将微流控方法形成的脂质体的大小分布的初步数据与传统的散装酒精注射方法进行了比较。
We review a variety of micro- and nanoparticle formulations produced with microfluidic methods. A diverse variety of approaches to generate microscale and nanoscale particles has been reported. Here we emphasize the use of microfluidics, specifically microfluidic systems that operate in a continuous flow mode, thereby allowing continuous generation of desired particle formulations. The generation of semiconductor quantum dots, metal colloids, emulsions, and liposomes is considered. To emphasize the potential benefits of the continuous-flow microfluidic methodology for nanoparticle generation, preliminary data on the size distribution of liposomes formed using the microfluidic approach is compared to the traditional bulk alcohol injection method.