Maleimide-functionalized carboxymethyl cellulose: A novel mucoadhesive polymer for transmucosal drug delivery.
Maleimide-functionalized carboxymethyl cellulose: A novel mucoadhesive polymer for transmucosal drug delivery.
复制标题
马来酰亚胺功能化羧甲基纤维素：一种用于跨粘膜药物输送的新型粘膜粘附聚合物。
DOI：
10.1016/j.carbpol.2022.119368
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发表时间：
2022
影响因子：
11.2
通讯作者：
Prasopchai Tonglairoum Patrojanasophon
中科院分区：
文献类型：
--
作者：
Chaiyakarn Pornpitchanarong;T. Rojanarata;P. Opanasopit;T. Ngawhirunpat;M. Bradley;Prasopchai Tonglairoum Patrojanasophon
本研究的目的是开发一种新型的粘膜粘附聚合物的药物输送应用的基础上N-（2-氨乙基）马来酰亚胺官能化的羧甲基纤维素，其中的材料的重量比进行了调整，以探索提供最高的马来酰亚胺含量的聚合物的条件。聚合物的合成从N-（2-氨乙基）马来酰亚胺，这是共轭羧甲基纤维素与其粘膜粘附性能进行了检查，拉伸试验，流变学，和流通分析和他们的生物相容性评估的人牙龈成纤维细胞系（HGF-1）。将抗炎药物苄达明装载到基于粘膜粘附聚合物的片剂中，并用于展示合成聚合物的应用。通过马来酰亚胺部分和粘蛋白之间的相互作用，该聚合物表现出上级羧甲基纤维素的粘膜粘附能力。功能化聚合物还具有控制释放苄达明的能力与Higuchi的释放模型，并被证明是一个潜在的候选人在粘膜粘附药物输送。
The objective of this research was to develop a novel mucoadhesive polymer for drug delivery applications based onN-(2-aminoethyl) maleimide-functionalized carboxymethyl cellulose in which the weight ratios of the materials were tuned to explore the condition providing the highest maleimide content on the polymer. The polymers were synthesized fromN-(2-aminoethyl) maleimide that was conjugated to carboxymethyl cellulose with their mucoadhesive properties examined by tensile testing, rheology, and flow-through analysis and their biocompatibilities evaluated on the human gingival fibroblast cell line (HGF-1). The anti-inflammatory drug benzydamine was loaded into mucoadhesive-polymer-based tablets and used to demonstrate the application of the synthesized polymer. The polymer exhibited superior mucoadhesive capability compared to carboxymethyl cellulose through the interaction between maleimide moiety and mucin. The functionalized polymer also possessed the ability to control the release of benzydamine with Higuchi's release model and was proven to be a potential candidate in mucoadhesive drug delivery.