THE ORGANIZATION OF AFFERENT-PROJECTIONS TO THE MIDBRAIN PERIAQUEDUCTAL GRAY OF THE RAT
THE ORGANIZATION OF AFFERENT-PROJECTIONS TO THE MIDBRAIN PERIAQUEDUCTAL GRAY OF THE RAT
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DOI：
10.1016/0306-4522(82)90157-9
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发表时间：
1982-01-01
期刊：
影响因子：
3.3
通讯作者：
BEITZ, AJ
中科院分区：
文献类型：
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作者：
BEITZ, AJ
应用逆行追踪技术研究了大鼠中脑导水管周围灰质的传入纤维投射。将辣根过氧化物酶离子导入22只实验动物的中脑导水管周围灰质和6只对照动物的中脑导水管周围灰质附近区域。利用逆行运输方法允许的传入投射的定量分析，不仅整个导水管周围灰质，但也到其4个固有的分区。对这个中脑区域的最大皮质输入来自内侧前额叶皮层的24和32区。基底前脑为导水管周围灰质提供了重要的输入;这主要来自同侧、外侧和内侧视前区以及Broca斜角带的水平分支。下丘脑向中央灰质提供最大的下行输入。在下丘脑内内侧核、下丘脑外侧区、下丘脑后区、下丘脑前区、穹窿周围核和灰结节区有大量标记细胞。最大的中脑输入到导水管周围灰质来自楔状核和黑质。中脑导水管周围灰质有许多内在的联系，在每种情况下，在注射部位的上方和下方都含有大量的标记细胞。在中脑和峡部区域含有显著标记的其他结构包括楔下核、腹侧被盖区、蓝斑和臂旁核。延髓和脑桥的网状结构提供了最大的输入到导水管周围灰质从下脑干。中缝大核和上级中央核也向中央灰质提供重要的纤维投射。三叉神经复合体和脊髓都向中脑的这个区域提供少量输入。中脑导水管周围灰质的传入投射来源广泛，并允许该中脑区域受到运动、感觉和边缘系统结构的影响。提供的证据表明，中央灰质的4个分区接收来自脑干和更高的脑结构的差异投影。
The retrograde transport technique was utilized to investigate the afferent projections to the periaqueductal gray of the rat. Iontophoretic injections of horseradish peroxidase were made into the periaqueductal gray of 22 experimental animals and into regions adjacent to the periaqueductal gray in 6 control animals. Utilization of the retrograde transport method permitted a quantitative analysis of the afferent projections not only to the entire periaqueductal gray, but also to each of its 4 intrinsic subdivisions. The largest cortical input to this midbrain region arises from areas 24 and 32 in the medial prefrontal cortex. The basal forebrain provides a significant input to the periaqueductal gray; this arises predominantly from the ipsilateral, lateral and medial preoptic areas and from the horizontal limb of the diagonal band of Broca. The hypothalamus provides the largest descending input to the central gray. Numerous labeled cells occurred in the entromedial hypothalamic nucleus, the lateral hypothalamic area, the posterior hypothalamic area, the anterior hypothalamic area, the perifornical nucleus and the area of the tuber cinereum. The largest mesencephalic input to the periaqueductal gray arises from the nucleus cuneiformis and the substantia nigra. The periaqueductal gray has numerous intrinsic connections and contains a significant number of labeled cells both above and below the injection site in each case. Other structures containing significant label in the midbrain and isthmus region included the nucleus subcuneiformis, the ventral tegmental area, the locus coeruleus and the parabrachial nuclei. The medullary and pontine reticular formation provide the largest input to the periaqueductal gray from the lower brain stem. The midline raphe magnus and superior central nucleus also supply a significant fiber projection to the central gray. Both the trigeminal complex and the spinal cord provide a minor input to this region of the midbrain. The sources of afferent projections to the periaqueductal gray are extensive and allow this midbrain region to be influenced by motor, sensory and limbic structures. Evidence is provided which indicates that the 4 subdivisions of the central gray receive differential projections from the brain stem and from higher brain structures.