Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: Maintenance of redox potential in a low oxygen environment
Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: Maintenance of redox potential in a low oxygen environment
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DOI：
10.1210/jc.2004-1513
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发表时间：
2005-02-01
影响因子：
5.8
通讯作者：
Burton, GJ
中科院分区：
文献类型：
--
作者：
Jauniaux, E;Hempstock, J;Burton, GJ
多元醇是通过还原醛糖和酮糖形成的糖醇。在低氧条件下生产是有利的，此时它可以提供生产乳酸的替代手段，用于调节吡啶核苷酸的氧化-还原平衡。多元醇还充当重要的有机渗透剂和细胞膜组分的前体。我们测量了5-12周胎龄正常人妊娠的母体血清、绒毛间液、体腔液和羊水中游离糖和多元醇的浓度。果糖，肌醇，山梨糖醇，甘露糖醇，核糖醇的浓度显着高于体腔液和羊水比母体血清，但相反的情况下，葡萄糖和甘油。绒毛间液中肌醇、甘露醇和山梨醇的浓度也显著高于母体血清中的浓度。这些结果表明，多元醇途径，被认为是残留在成人组织中，是高度活跃的人怀孕期间的早期孕体。该途径可能有助于维持ATP浓度和细胞氧化还原电位，而胚胎在低氧环境中发育。多元醇也可能在人类孕体的发育中发挥重要的生理作用，可能通过胎盘吸收水和溶质并扩张妊娠囊。
Polyols are sugar alcohols formed by the reduction of aldoses and ketoses. Production is favored under conditions of low oxygenation, when it may provide an alternative means to production of lactate for regulating the oxidation-reduction balance of pyridine nucleotides. Polyols also act as important organic osmolytes and as precursors of cell membrane components. We measured free sugar and polyol concentrations in matched samples of maternal serum, intervillous fluid, coelomic fluid, and amniotic fluid from normal human pregnancies at 5-12 wk gestational age. The concentrations of fructose, inositol, sorbitol, erythritol, and ribitol were significantly higher in coelomic and amniotic fluids than in maternal serum, but the reverse was the case for glucose and glycerol. Intervillous fluid concentrations of inositol, mannitol, and sorbitol were also significantly higher than those in maternal serum. These results demonstrate that the polyol pathway, considered vestigial in adult tissues, is highly active in the human conceptus during early pregnancy. The pathway may serve to maintain ATP concentrations and cellular redox potential while the embryo develops in a low oxygen environment. Polyols may also play important physiological roles in development of the human conceptus, possibly drawing water and solutes across the placenta and expanding the gestational sac.