Near Full-Length Genome Identification of a Novel HIV-1 Recombinant Form (CRF01_AE/CRF07_BC) in Zhejiang, China.
Near Full-Length Genome Identification of a Novel HIV-1 Recombinant Form (CRF01_AE/CRF07_BC) in Zhejiang, China.
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DOI：
10.1089/aid.2016.0114
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发表时间：
2016-09
影响因子：
1.5
通讯作者：
PengXiaorong;Li-junXu;XieTiansheng;LiuFumin;WuNanping
中科院分区：
文献类型：
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作者：
PengXiaorong;Li-junXu;XieTiansheng;LiuFumin;WuNanping
摘要CRF01_AE和CRF07_BC是我国目前流行的两种主要的重组体。此外，最近在中国发现了CRF01_AE和CRF07_BC之间的多种独特重组形式（URF）。在此我们检测到一个新的重组体CRF07_BC/CRF01_AE，其基因组结构与以前报道的其他URF有明显的不同。对15 zj 032近全长序列的系统发育分析表明，CRF01_AE的三个区域插入CRF07_BC骨架。近年来，新型URF的不断出现意味着不同亚型的HIV-1重叠感染在中国很常见，应引起足够的重视。
Abstract CRF01_AE and CRF07_BC are the two major circulating recombinant forms (CRFs) in China. Furthermore, many kinds of unique recombinant forms (URFs) between CRF01_AE and CRF07_BC were recently identified in China. Here we detected a novel recombinant of CRF07_BC/CRF01_AE, whose genome structure is distinctly different from other URFs reported before. The phylogenetic analysis of the near full-length sequence of 15zj032 reveals that three regions of CRF01_AE insert into the CRF07_BC backbone. Recently, the continued emergence of novel URFs implies that super infections of different subtypes of HIV-1 are common in China and should be given enough importance.