Increased Serum Levels of Interleukin-18,-23 and-17 in Chinese Patients with Alzheimer's Disease
Increased Serum Levels of Interleukin-18,-23 and-17 in Chinese Patients with Alzheimer's Disease
复制标题
中国阿尔茨海默病患者血清白介素-18、-23和-17水平升高
DOI：
10.1159/000360606
复制
发表时间：
2014-01-01
影响因子：
2.4
通讯作者：
Cheng, Qi
中科院分区：
文献类型：
--
作者：
Chen, Jin-Mei;Jiang, Guo-Xin;Cheng, Qi
目的：目的检测阿尔茨海默病（AD）患者血清白细胞介素（IL）-18、IL-23和IL-17水平，探讨3种细胞因子与相关指标的相关性。研究方法：采用酶联免疫吸附试验（ELISA）检测了53例AD患者和53例年龄、性别相匹配的健康对照者血清IL-18、IL-23和IL-17水平。结果：AD患者血清IL-18、IL-23和IL-17水平均显著高于对照组。观察到女性AD患者的IL-23血清水平显著高于男性AD患者（p = 0.049）。此外，所有AD患者的IL-18与MMSE评分之间存在显著负相关（r（s）=-0.356，p = 0.011）。结论：AD患者血清IL-18、IL-23和IL-17水平升高，且存在性别差异。此外，IL-18可能与AD的严重程度相关。(C)2014年S. Karger AG，巴塞尔
Aims: To evaluate the serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with Alzheimer's disease (AD), and explore correlations between the three cytokines and relevant parameters. Methods: Serum concentrations of IL-18, IL-23 and IL-17 were measured by ELISA for 53 AD patients and 53 sex- and age-matched healthy controls in a community of elderly individuals in a Shanghai suburb. Results: Serum concentrations of IL-18, IL-23 and IL-17 were significantly higher in AD patients than controls. The serum level of IL-23 was observed to be significantly higher (p = 0.049) in female AD patients than male AD patients. In addition, a significantly inverse correlation was found between IL-18 and MMSE score (r(s) = -0.356, p = 0.011) for all AD patients. Conclusion: Elevated IL-18, IL-23 and IL-17 levels are observed in AD patients and differences may exist between males and females. Besides, IL-18 may correlate with the severity of AD. (C) 2014 S. Karger AG, Basel