Effect of increased excursion of the ankle on the severity of acute eccentric contraction-induced strain injury in the gastrocnemius - An in vivo rat study
Effect of increased excursion of the ankle on the severity of acute eccentric contraction-induced strain injury in the gastrocnemius - An in vivo rat study
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DOI：
10.1177/0363546503262199
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发表时间：
2004-07-01
影响因子：
4.8
通讯作者：
Nakajima, H
中科院分区：
文献类型：
--
作者：
Song, H;Nakazato, K;Nakajima, H
背景：虽然经常使用肌肉拉伤模型，但通常使用包括手术干预在内的高侵入性操作来制作这些模型。研究设计：对照实验室研究。方法：动物随机分为两组：小活动度组(90°~105度，n=10)和大活动度组(90度~125度，n=10)。结果：大活动度组治疗后第1、2、3天等长强直力明显低于治疗前对照组。在小范围活动组中未观察到这种减少。在10天的研究期间，大范围运动组均观察到明显的病理损伤。结论：采用体内模型，运动范围越大导致的偏心收缩损伤越大。临床相关性：该体内模型有助于阐明劳损的预防和恢复机制。
Background: Although muscle strain injury models are frequently employed, highly invasive procedures, including surgical intervention, are typically used to produce these models. In this study, a minimally invasive model of acute strain injury was produced with a single eccentric contraction.Hypothesis: The authors tested whether the severity of strain injury in the in vivo gastrocnemius depends on the excursion of the ankle.Study Design: Controlled laboratory study.Methods: Animals were randomly assigned to 2 groups: a small range of motion group (90degrees-105degrees, n = 10) and a large range of motion group (90degrees-125degrees, n = 10). Tetanically activated gastrocnemius muscles with percutaneous electrical stimulation were simultaneously elongated by forced dorsiflexion of the ankle joint.Results: Isometric tetanic force of the large range of motion group was significantly lower than the pretreatment control 1, 2, and 3 days after treatment. Such reduction was not observed in the small range of motion group. Apparent pathologic damage was observed in the large range of motion group throughout the study period of 10 days.Conclusions: A larger range of motion causes more damage in eccentric contraction by using the in vivo model.Clinical Relevance: This in vivo model is useful to elucidate mechanisms of prevention and recovery of strain injury.