Integration of immune-metabolic signals to preserve healthy aging.
Integration of immune-metabolic signals to preserve healthy aging.
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DOI：
10.1016/j.tma.2020.07.005
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发表时间：
2020
影响因子：
--
通讯作者：
Goldberg EL
中科院分区：
文献类型：
--
作者：
Goldberg EL
炎症是一个广义的术语，指的是体内一系列精心平衡的程序。这些途径对于检测入侵微生物、控制感染传播和指示适当的免疫反应以消除病原体至关重要。在衰老过程中，重要的调节机制恶化，引起持续的低度炎症，从而导致代谢失调、免疫衰老和认知能力下降等慢性疾病。了解衰老病理生物学的这一方面是揭示疾病背后与年龄相关的炎症的来源和原因的关键。
Inflammation is a broad term that refers to a collection of carefully balanced programs in the body. These pathways are essential for detecting invading microorganisms, controlling the spread of infection, and instructing appropriate immune responses to eliminate pathogens. During aging there is deterioration of important regulatory mechanisms, giving rise to persistent low-grade inflammation that drives chronic conditions such as metabolic dysregulation, immune senescence, and cognitive decline. Understanding this aspect of the pathobiology of aging is key to uncovering the source(s) and cause(s) of age-related inflammation that underlies disease.