Current-voltage relationship of the basolateral membrane of a tight epithelium.

Current-voltage relationship of the basolateral membrane of a tight epithelium.
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紧密上皮基底外侧膜的电流-电压关系。

DOI:
10.1016/0005-2736(79)90405-x
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发表时间:
1979
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
M. S. Ifshin
M. S. Ifshin
中科院分区:
--
文献类型:
--
作者:
N. Wills;D. Eaton;S. Lewis;M. S. Ifshin

文献摘要

被引文献

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多烯抗生素制霉菌素用于选择性地将兔降结肠的顶膜电阻降低至零,从而可以测量基底外侧膜的电流-电压曲线。 I-V 关系由 Goldman-Hodgkin-Katz 方程描述,允许计算基底外侧膜的 PNa/PK、PCl/PK 和 PK。人们发现 Cs+ 以类似于可兴奋膜中发现的方式阻止内向电流(浆膜 → 粘膜)。
The polyene antibiotic nystatin is used to reduce selectively to zero the apical membrane resistance of the rabbit descending colon, allowing the measurement of the current-voltage curve of the basolateral membrane. TheI—Vrelationship is described by the Goldman-Hodgkin-Katz equations allowing calculation ofPNa/PK,PCl/PKandPKfor the basolateral membrane. Cs+is found to block inward current (serosa → mucosa) in a manner similar to that found in excitable membranes.