EFFECTS OF PILOCARPINE ON MORPHOLOGY OF HUMAN OUTFLOW APPARATUS
EFFECTS OF PILOCARPINE ON MORPHOLOGY OF HUMAN OUTFLOW APPARATUS
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DOI：
10.1136/bjo.62.5.302
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发表时间：
1978-01-01
影响因子：
4.1
通讯作者：
ABRAHAM, S
中科院分区：
文献类型：
--
作者：
GRIERSON, I;LEE, WR;ABRAHAM, S
用2%或4%匹罗卡品局部治疗4次，每次间隔6小时，在去核前将流出器的形态学与未治疗的同龄患者的对照眼进行比较。在匹罗卡品组，巩膜骨刺向后内拉，使得治疗组巩膜骨刺与巩膜沟形成的夹角明显大于未治疗组。巩膜骨刺姿态的改变使角膜巩膜小梁之间的间隙变宽，内皮网扩张。施莱姆管内皮大液泡计数显示，皮罗卡品组大液泡发生率是对照组的2倍以上。显然，匹罗卡品会改变流出器官的结构，从而促进房水的排出。
The morphology of the outflow apparatus in human eyes treated topically with either 2 or 4% pilocarpine on 4 occasions at 6-h intervals before enucleation was compared with an untreated control series of eyes from patients in a similar age range. In the pilocarpine-treated group and scleral spur was pulled posteriorly and internally, so that the angle formed by the scleral spur and the scleral sulcus was significantly greater in the treated than the untreated series. The change in attitude of the scleral spur produced widening of the spaces between the corneoscleral trabeculae and distension of the endothelial meshwork. Counts of giant vacuoles in the endothelium of Schlemm''s canal showed that the incidence of giant vacuoles in the pilocarpine-treated group was greater than twice that in the controls. Apparently pilocarpine produces alterations in the configuration of the outflow apparatus which would promote the drainage of aqueous humor.