Reduced Testosterone Levels in Males with Lone Atrial Fibrillation
Reduced Testosterone Levels in Males with Lone Atrial Fibrillation
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DOI：
10.1002/clc.20423
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Zhu, Jianhua
中科院分区：
文献类型：
--
作者：
Lai, Jiangtao;Zhou, Dongchen;Zhu, Jianhua
背景：性激素在心血管疾病的发生发展中起重要作用。据报道，睾酮和雌二醇被下调的受试者与冠状动脉疾病和心力衰竭，但还没有被研究在心房颤动（AF）。假设：性激素水平可能与易感性孤立AF在mention.Methods：58名男性受试者谁有心电图证据阵发性或慢性AF和结构正常的心脏超声心动图进行了登记。如果受试者在3个月内服用血管紧张素转换酶抑制剂（ACEI）、血管紧张素受体阻滞剂（ARB）或他汀类药物，或有冠状动脉疾病、风湿性心脏病、心肌病、严重瓣膜病、甲状腺功能亢进或高血压病史，则排除受试者。从健康门诊人群中招募58名对照。血清总睾酮和雌二醇水平测定使用市售radioimmunoassociation.Results：睾酮的平均水平显着降低，与对照组相比（476纳克/分升与514纳克/分升，p = 0.005）的主题与张力AF。两组间雌二醇水平无显著差异（31.9 pg/ml vs 32.4 pg/ml，p = 0.789）。结论：睾酮水平降低可能与男性孤立性房颤的易感性有关。
Background: Sex hormones play an important role in the development of cardiovascular disease. Testosterone and estradiol have been reported to be down-regulated in subjects with coronary artery disease and heart failure, but has not been studied in atrial fibrillation (AF).Hypothesis: Levels of sex hormones may be associated with susceptibility to lone AF in men.Methods: Fifty-eight male subjects who had electrocardiographic evidence of paroxysmal or chronic AF and a structurally normal heart on echocardiography were enrolled. Subjects were excluded if they had been taking angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), or statins within 3 MO or had a history of coronary artery disease, rheumatic heart disease, cardiomyopathy, significant valvular disease, hyperthyroidism, or hypertension, Fifty-eight controls were recruited from a healthy outpatient population. Serum total testosterone and estradiol levels were determined using a commercially available radioimmunoassay.Results: Mean levels of testosterone were significantly lower in subjects with tone AF when compared with controls (476 ng/dl versus 514 ng/dl, p = 0,005). No significant differences were found in the estradiol levels between the 2 groups (31.9 pg/ml versus 32.4 pg/ml, p = 0.789).Conclusion: Reduced testosterone levels may be associated with susceptibility to lone AF in men.