Association Between Smoking, Acetaldehyde Dehydrogenase-2 1-1 Status, and Alcohol Drinking Among Taiwanese Polyvinyl Chloride Workers
Association Between Smoking, Acetaldehyde Dehydrogenase-2 1-1 Status, and Alcohol Drinking Among Taiwanese Polyvinyl Chloride Workers
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台湾聚氯乙烯工人吸烟、乙醛脱氢酶-2 1-1状态与饮酒之间的关系
DOI：
10.1097/00043764-200108000-00008
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发表时间：
2001
影响因子：
3.2
通讯作者：
T. Cheng
中科院分区：
文献类型：
--
作者：
Yi;H. Hsieh;Yen;T. Cheng
为探讨影响台湾劳工饮酒的因素，本研究以饮酒与吸烟、乙醛脱氢酶2（ALDH 2）、乙醇脱氢酶2（ADH 2）、肝功能异常史、B、C型肝炎病毒感染等为研究对象，进行相关性调查。研究对象包括207名自1992年以来定期随访肝功能的男性工人。通过1996年的访谈问卷获得与当前饮酒和吸烟习惯相关的信息，并从既往医学监测中获得肝功能和B和C型肝炎病毒感染史。采用聚合酶链反应/限制性片段多态性分析法检测ALDH 2和ADH 2基因型。结果显示，吸烟和ALDH 2 1-1状态与当前饮酒相关（分别为：比值比，23.3;P < 0.01和比值比，14.5;P < 0.05）。肝功能异常史或B和/或C型肝炎感染史与当前饮酒无关。似乎只有那些ALDH 2 1-1的吸烟者才会饮酒。我们的结论是，吸烟和遗传ALDH 2 1-1是最重要的决定因素，饮酒。除了医生在每年的健康检查中的医疗建议外，还应立即制定基于饮酒习惯和戒烟的工作场所健康促进计划，特别是对于那些表现出可能发生肝损伤的人。
To study the factors affecting alcohol consumption among Taiwanese workers, we conducted an investigation of the association between alcohol drinking and smoking, aldehyde dehydrogenase-2 (ALDH2) status, alcohol dehydrogenase-2 (ADH2) status, any history of abnormal liver function, and hepatitis B and C viral infection. The subjects included 207 male workers who had been followed-up with respect to liver function periodically since 1992. Information relating to current alcohol consumption and smoking habits was obtained by an interviewer-administered questionnaire in 1996, and any history of liver function and hepatitis B and C virus infection was obtained from previous medical surveillance. Genotypes of ALDH2 and ADH2 were determined by polymerase chain reaction/restriction fragment polymorphism assay. Results have revealed that smoking and ALDH2 1–1 status were associated with current alcohol consumption (respectively: odds ratio, 23.3;P < 0.01 and odds ratio, 14.5;P < 0.05). Neither a history of abnormal liver function nor a history of hepatitis B and/or C infection was associated with current alcohol consumption. It seems that only those with ALDH2 1–1 who are smokers consume alcohol. We conclude that smoking and inherited ALDH2 1–1 are the most important determinants of alcohol consumption. In addition to the medical advice of physicians in their yearly health check-ups, worksite health-promotion programs based on both alcohol consumption habits and smoking cessation should be instituted forthwith, particularly for those who demonstrate the potential for developing liver damage.