Transverse patterning dissociates human EEG theta power and hippocampal BOLD activation.
Transverse patterning dissociates human EEG theta power and hippocampal BOLD activation.
复制标题
横向模式分离人类脑电图 theta 功率和海马 BOLD 激活。
DOI：
10.1111/j.1469-8986.2008.00719.x
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Constable,RTodd
中科院分区：
文献类型：
--
作者：
Meltzer,JedA;Fonzo,GregA;Constable,RTodd
Theta振荡（4-8 Hz）在人类记忆的脑电图（EEG）研究中经常被调制，而重叠频率主导啮齿动物海马EEG。theta反应性和海马功能磁共振成像激活之间的一种新的平行性表明，人类和啮齿动物中的theta活动之间具有同源性，代表了参与记忆的皮质-海马相互作用的过程。在本研究中，我们研究了EEG反应性的关系记忆任务，诱导负海马血氧水平依赖（BOLD）信号的变化，相比，一个nonrelational控制条件的性能。关系试验导致θ增加，α减少。低分辨率电磁脑断层扫描分别估计额叶中线和顶叶中线皮质的局部θ和α调制，这两者在该任务中均表现出负BOLD响应。因此，θ和α动力学与正BOLD激活是分离的，并且事实上可能与负BOLD响应共定位。
Theta oscillations (4–8 Hz) are often modulated in human electroencephalogram (EEG) studies of memory, whereas overlapping frequencies dominate rodent hippocampal EEG. An emerging parallelism between theta reactivity and hippocampal functional magnetic resonance imaging activation has suggested a homology between theta activity in humans and rodents, representing a process of cortico‐hippocampal interaction involved in memory. In the present study, we investigated EEG reactivity during performance of a relational memory task that induces a negative hippocampal blood oxygenation level dependent (BOLD) signal change, compared to a nonrelational control condition. Relational trials induced theta increases and alpha decreases. Low Resolution Electromagnetic Brain Tomography estimates localized theta and alpha modulation to frontal midline and parietal midline cortices, respectively, both of which exhibit negative BOLD responses in this task. Thus, theta and alpha dynamics are dissociable from positive BOLD activation, and may, in fact, colocalize with negative BOLD responses.