Effect of environmental contaminants on nasal lysozyme secretions
Effect of environmental contaminants on nasal lysozyme secretions
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DOI：
10.1016/s0048-9697(01)00871-3
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发表时间：
2002-02-04
影响因子：
9.8
通讯作者：
Noble, RE
中科院分区：
文献类型：
--
作者：
Noble, RE
人鼻分泌物由溶菌酶和白蛋白作为其主要蛋白质组分组成。溶菌酶是一种抗微生物物质，由鼻浆液细胞产生，而白蛋白主要从鼻血管通透性增加中获得。我们测量了各种非感染性环境污染物的挑战后，鼻分泌物中的溶菌酶水平。给出的方法提出了一种简单，快速的方法收集鼻分泌物，并确定其溶菌酶含量，一种技术，可用于主机的环境刺激物。(C)2002 Elsevier Science B.V.保留所有权利。
Human nasal secretions are comprised of lysozyme and albumin as their main protein components. Lysozyme, an anti-microbial substance, is produced by nasal serous cells while albumin is obtained, primarily, from increased nasal vasculature permeability. We measured lysozyme levels in nasal secretions following challenge by a variety of non-infectious environmental contaminants. The methodology given presents a simple and rapid method of collecting nasal secretions and determining their lysozyme content, a technique which can be used for a host of environmental irritants. (C) 2002 Elsevier Science B.V. All rights reserved.