Role of respiratory syncytial virus in acute otitis media: implications for vaccine development.
Role of respiratory syncytial virus in acute otitis media: implications for vaccine development.
复制标题
呼吸道合胞病毒在急性中耳炎中的作用：对疫苗开发的影响。
DOI：
10.1016/j.vaccine.2006.10.045
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发表时间：
2007
期刊：
影响因子：
5.5
通讯作者：
Chonmaitree,Tasnee
中科院分区：
文献类型：
--
作者：
Patel,JanakA;Nguyen,DangT;Revai,Krystal;Chonmaitree,Tasnee
我们在此总结了10年来在本中心进行的急性中耳炎（AOM）的各种病毒学研究结果。在566名AOM儿童中，呼吸道合胞病毒（RSV）是中耳液或鼻洗液中最常见的病毒;在所有儿童中发现了16%，在病毒阳性儿童中发现了38%。71%的RSV患儿年龄在1岁或以上，明显大于所有其他病毒的总和（P=0.045）。RSV感染与引起AOM的常见病原菌有关。过去开发RSV疫苗的努力强调预防婴儿下呼吸道感染，这是一个更严重的问题，但比AOM更不常见。我们的研究结果表明，仅对年龄较大的儿童感染有效的RSV疫苗可能在预防AOM（最常见的儿科疾病）方面具有价值。
We summarize herein the results of various virologic studies of acute otitis media (AOM) conducted at our site over a 10-year period. Among 566 children with AOM, respiratory syncytial virus (RSV) was the most common virus identified in either middle ear fluid or nasal wash; it was found in 16% of all children and 38% of virus-positive children. Seventy-one percent of the children with RSV were 1 year of age or older, which was significantly older than all other viruses combined (P=0.045). RSV infection was associated with the common bacterial pathogens causing AOM. Past efforts to develop vaccines for RSV have emphasized prevention of lower respiratory tract infection in infants, which is a more serious problem but less common than AOM. Our results suggest that RSV vaccines that work only against infection in older children may have value in preventing AOM, the most common pediatric disease.