Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences
Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences
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DOI：
10.1192/bjp.bp.110.083808
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发表时间：
2011-07-01
影响因子：
10.5
通讯作者：
Fananas, Lourdes
中科院分区：
文献类型：
--
作者：
Alemany, Silvia;Arias, Barbara;Fananas, Lourdes
研究背景儿童期逆境和精神病之间的关系可能涉及其他因素，如遗传变异，这可以帮助我们理解为什么不是每个暴露于不良事件的人在以后的生活中都会出现精神病症状。目的我们研究了儿童期虐待和忽视对成年后积极和消极精神病样经历的影响，以及BDNF-Val 66 Met多态性的潜在调节作用。结果儿童期虐待对精神病样经历的积极维度有很强的独立影响（β = 0.16，s.e.）。= 0.05，P = 0.002）。此外，这种关联受到BDNF-Val 66 Met多态性的调节（β = 0.27，标准偏差）= 0.10，P = 0.004）。结论儿童期虐待暴露的个体更有可能报告积极的精神病样体验。与携带瓦尔/瓦尔基因型的个体相比，Met携带者在儿童期遭受虐待时报告了更多积极的精神病样经历。因此，所观察到的基因环境相互作用效应可能是部分负责个体差异，在儿童期虐待。
BackgroundThe well-established relationship between childhood adversity and psychosis is likely to involve other factors such as genetic variants that can help us to understand why not everyone exposed to adverse events develops psychotic symptoms later in life.AimsWe investigated the influence of childhood abuse and neglect on positive and negative psychotic-like experiences in adulthood and the potential moderating effect of the BDNF-Val66Met polymorphism.MethodPsychotic-like experiences and childhood adversity were assessed in 533 individuals from the general population.ResultsChildhood abuse showed a strong independent effect on the positive dimension of psychotic-like experiences (beta = 0.16, s.e. = 0.05, P = 0.002). Furthermore, this association was moderated by the BDNF-Val66Met polymorphism (beta = 0.27, s.e. = 0.10, P = 0.004).ConclusionsIndividuals exposed to childhood abuse are more likely to report positive psychotic-like experiences. Met carriers reported more positive psychotic-like experiences when exposed to childhood abuse than did individuals carrying the Val/Val genotype. Therefore, the observed gene environment interaction effect may be partially responsible for individual variation in response to childhood abuse.