Simvastatin decreases aldehyde production derived from lipoprotein oxidation
Simvastatin decreases aldehyde production derived from lipoprotein oxidation
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DOI：
10.1016/s0002-9149(98)01071-6
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发表时间：
1999-03-15
影响因子：
2.8
通讯作者：
Masana, L
中科院分区：
文献类型：
--
作者：
Girona, J;La Ville, AE;Masana, L
已知他汀类药物治疗可降低血浆和低密度脂蛋白（LDL）胆固醇水平，从而预防和消退动脉粥样硬化。最近有人提出，他汀类药物的作用也可能对动脉粥样硬化斑块形成中涉及的其他机制有直接影响。因此，我们研究了辛伐他汀是否对血浆脂蛋白具有抗氧化作用。LDL和高密度脂蛋白（HDL）的氧化速率通过共轭二烯的形成来测量（体外）和（体内），在加入和不加入浓度递增的辛伐他汀的情况下，以及在接受和不接受辛伐他汀治疗的患者中。增加辛伐他汀浓度与滞后期呈强相关，LDL样品中FDR最大速率与最大二烯产生呈负相关（r（2）=+0.97，p
Treatment with statins are known to lower plasma and low-density liporprotein (LDL) cholesterol levels with resultant prevention and regression of atherosclerosis. It has been recently suggested that the action of the statins may also have a direct effect on other mechanisms involved;in the atherosclerotic plague formation. Thus, we investigated whether simvastatin could have an antioxidant effect on plasma lipoproteins. The rate of oxidation of LDL and high-density lipoproteins (HDL) was measured by conjugated diene formation with and without the addtion of increasing concentrations of simvastatin tin vitro) and in patients with and without treatment with simvastatin (in vivo). A strong correlation was observed between increasing simvastatin concentration and the lag phase a negative correlation was observed fdr maximal rate and maximum diene production in LDL samples (r(2) = +0.97, p