The multifaceted contributions of mitochondria to cellular metabolism.

The multifaceted contributions of mitochondria to cellular metabolism.
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DOI:
10.1038/s41556-018-0124-1
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发表时间:
2018-07
影响因子:
21.3
通讯作者:
Haigis MC
Haigis MC
中科院分区:
生物学1区
文献类型:
--
作者:
Spinelli JB;Haigis MC

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虽然线粒体作为细胞的动力来源而受到经典的赞赏,但线粒体的代谢功能远远超出了生物能量学。线粒体分解代谢营养物质以获得能量,产生生物合成的大分子前体,划分代谢物以维持氧化还原稳态,并作为代谢废物管理的枢纽。我们讨论的重要性,这些作用在正常生理和疾病。
Although classically appreciated for their role as the powerhouse of the cell, the metabolic functions of mitochondria reach far beyond bioenergetics. Mitochondria catabolize nutrients for energy, generate biosynthetic precursors for macromolecules, compartmentalize metabolites for the maintenance of redox homeostasis, and function as hubs for metabolic waste management. We discuss the importance of these roles in both normal physiology and in disease.
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