The multifaceted contributions of mitochondria to cellular metabolism.
The multifaceted contributions of mitochondria to cellular metabolism.
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DOI:
10.1038/s41556-018-0124-1
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发表时间:
2018-07
影响因子:
21.3
通讯作者:
Haigis MC
中科院分区:
文献类型:
--
作者:
Spinelli JB;Haigis MC
Although classically appreciated for their role as the powerhouse of the cell, the metabolic functions of mitochondria reach far beyond bioenergetics. Mitochondria catabolize nutrients for energy, generate biosynthetic precursors for macromolecules, compartmentalize metabolites for the maintenance of redox homeostasis, and function as hubs for metabolic waste management. We discuss the importance of these roles in both normal physiology and in disease.
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