Glucocorticoids decrease thyrotropin-releasing hormone messenger ribonucleic acid expression in the paraventricular nucleus of the human hypothalamus
Glucocorticoids decrease thyrotropin-releasing hormone messenger ribonucleic acid expression in the paraventricular nucleus of the human hypothalamus
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DOI：
10.1210/jc.2004-1430
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发表时间：
2005-01-01
影响因子：
5.8
通讯作者：
Fliers, E
中科院分区：
文献类型：
--
作者：
Alkemade, A;Unmehopa, UA;Fliers, E
糖皮质激素影响下丘脑室旁核TRH mRNA表达的方式尚不清楚。鉴于其与库欣综合征和抑郁症的相关性，我们通过TRH mRNA定量原位杂交方法测定了尸检获得的人下丘脑中TRH mRNA的表达。在皮质类固醇治疗的受试者（n = 10）中，TRH mRNA杂交信号与匹配的对照受试者（n = 10）相比降低（Mann-Whitney U检验，P = 0.02）。由此推断，库欣综合征或抑郁症患者中存在的皮质醇增多症可能通过降低下丘脑TRH表达而导致血清TSH降低或抑郁症状。
The way glucocorticoids affect TRH mRNA expression in the paraventricular nucleus of the hypothalamus is still unclear. In view of its relevance for Cushing's syndrome and depression, we measured TRH mRNA expression in human hypothalami obtained at autopsy by means of quantitative TRH mRNA in situ hybridization. In corticosteroid-treated subjects ( n = 10), TRH mRNA hybridization signal was decreased as compared with matched control subjects ( n = 10) (Mann-Whitney U test, P = 0.02). By inference, hypercortisolism as present in patients with Cushing's syndrome or major depression may contribute to lower serum TSH or symptoms of depression by lowering hypothalamic TRH expression.