Vitamin D and Inflammatory Cytokines in Healthy and Preeclamptic Pregnancies.
Vitamin D and Inflammatory Cytokines in Healthy and Preeclamptic Pregnancies.
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DOI：
10.3390/nu7085293
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发表时间：
2015-08-04
期刊：
影响因子：
5.9
通讯作者：
Halhali A
中科院分区：
文献类型：
--
作者：
Barrera D;Díaz L;Noyola-Martínez N;Halhali A
子痫前期是一种以高血压和蛋白尿为特征的妊娠疾病。在几种疾病中，炎症细胞因子的失衡和维生素D代谢的改变已被报道在子痫前期。骨化三醇对炎性细胞因子的影响已被证实。在健康的孕妇中，有向Th2细胞因子谱的转变，这对于适当的妊娠结局是必要的。与正常妊娠相比，在子痫前期妇女中观察到高促炎和低抗炎细胞因子水平。子痫前期与骨化三醇水平低有关，维生素D缺乏与这种疾病发展的高风险有关。胎盘是骨化三醇和细胞因子的来源和靶点，胎盘功能障碍与子痫前期有关。因此，本文综述了未妊娠、妊娠和子痫前期妇女血清骨化三醇水平以及健康和子痫前期妊娠胎儿胎盘维生素D代谢的研究进展。此外，循环和胎胎盘炎症细胞因子在健康和子痫前期妊娠进行了综述。最后，骨化三醇对胎盘促炎细胞因子的影响也进行了探讨。总之，母体和胎盘骨化三醇水平在子痫前期较低，这可以解释，至少部分，在这种疾病中，高促炎细胞因子水平。
Preeclampsia is a pregnancy disease characterized by hypertension and proteinuria. Among several disorders, the imbalance of inflammatory cytokines and the alteration of vitamin D metabolism have been reported in preeclampsia. The effects of calcitriol upon inflammatory cytokines has been demonstrated. In healthy pregnant women there is a shift toward a Th2 cytokine profile, which is necessary for an adequate pregnancy outcome. As compared with normal pregnancy, high pro-inflammatory and low anti-inflammatory cytokine levels have been observed in preeclamptic women. Preeclampsia has been associated with low calcitriol levels and vitamin D deficiency is correlated with a higher risk of the development of this disease. It has been demonstrated that placenta is a source as well as the target of calcitriol and cytokines and placental dysfunction has been associated with preeclampsia. Therefore, the present manuscript includes a review about serum calcitriol levels in non-pregnant, pregnant, and preeclamptic women as well as a review on the fetoplacental vitamin D metabolism in healthy and preeclamptic pregnancies. In addition, circulating and fetoplacental inflammatory cytokines in healthy and preeclamptic pregnancies are reviewed. Finally, the effects of calcitriol upon placental pro-inflammatory cytokines are also explored. In conclusion, maternal and placental calcitriol levels are low in preeclampsia which may explain, at least in part, high pro-inflammatory cytokine levels in this disease.