SLIGHTLY DELETERIOUS MUTANT SUBSTITUTIONS IN EVOLUTION
SLIGHTLY DELETERIOUS MUTANT SUBSTITUTIONS IN EVOLUTION
复制标题
DOI：
10.1038/246096a0
复制
发表时间：
1973-01-01
期刊：
影响因子：
64.8
通讯作者：
OHTA, T
中科院分区：
文献类型：
--
作者：
OHTA, T
分子遗传学的最新进展对进化理论产生了很大的影响，特别是分子进化的中性突变-随机漂移假说1,2引起了人们的极大兴趣。群体中通过随机遗传漂变的中性突变替代的概念可以扩展到包括非常轻微的有害突变的随机固定，这些突变被选择反对的机会大于被选择的机会3,4。如果这类突变替代是重要的，我们就可以预测，在小种群中或在物种形成时期，进化是迅速的。在这里，我将整理观察到的事实，这些事实表明这门课实际上很重要。
RECENT advances in molecular genetics have had a great deal of influence on evolutionary theory, and in particular, the neutral mutation-random drift hypothesis of molecular evolution1,2has stimulated much interest. The concept of neutral mutant substitution in the population by random genetic drift can be extended to include random fixation of very slightly deleterious mutations which have more chance of being selected against than of being selected for3,4. If this class of mutant substitution is important, we can predict that the evolution is rapid in small populations or at the time of speciation5. Here I shall organize the observed facts which indicate that this class is in fact important.