DNA microarrays in clinical oncology
DNA microarrays in clinical oncology
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DOI：
10.1200/jco.2002.20.7.1932
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发表时间：
2002-04-01
影响因子：
45.3
通讯作者：
Golub, TR
中科院分区：
文献类型：
--
作者：
Ramaswamy, S;Golub, TR
基因表达异常对肿瘤的发生和发展至关重要。然而，我们对所有在人类癌症中异常表达的基因缺乏全面的了解。最近，DNA微阵列已被用于获得人类癌症基因表达的全局视图，并确定可能对诊断和治疗重要的遗传标记。我们回顾了这些新工具的临床应用，讨论了一些重要的最新研究，确定了这一新兴研究领域的有前途的研究途径，并讨论了表达谱分析对临床肿瘤学的可能影响。
Aberrant gene expression is critical for tumor initiation and progression. However, we lack a comprehensive understanding of all genes that are aberrantly expressed in human cancer. Recently, DNA microarrays have been used to obtain global views of human cancer gene expression and to identify genetic markers that might be important for diagnosis and therapy. We review clinical applications of these novel tools, discuss some important recent studies, identify promising avenues of research in this emerging field of study, and discuss the likely impact that expression profiling will have on clinical oncology.