Combined treatment of osteosarcoma of the spine.
Combined treatment of osteosarcoma of the spine.
复制标题
脊柱骨肉瘤的综合治疗。
DOI：
10.1097/00006123-198812000-00005
复制
发表时间：
1988
期刊：
影响因子：
4.8
通讯作者：
G. Krol
中科院分区：
文献类型：
--
作者：
N. Sundaresan;G. Rosen;A. Huvos;G. Krol
我们回顾了35年来24例脊柱骨肉瘤患者的临床特征和治疗结果。男性14例，女性10例，年龄13 ~ 71岁。13例患者的肿瘤是新发的，11例继发于其他疾病。所有患者均表现为疼痛，16例（67%）有神经功能障碍。患者分为两个治疗组。1949年至1977年收治的13例患者通常行有限肿瘤切除和外放射治疗。第二组，从1978年到1984年治疗的11例患者，接受了更积极的手术切除，联合化疗以及肿瘤床局部放疗。在第二组中，有5名长期幸存者，只有1名患者在治疗期间发生转移性疾病。未能获得局部控制是治疗失败的主要原因。椎体切除及联合化疗是脊柱成骨性肉瘤的最佳治疗方法。
We reviewed the clinical features and results of treatment in 24 patients with osteogenic sarcoma of the spine treated over a 35-year period. There were 14 male and 10 female patients 13 to 71 years old. The tumor arose de novo in 13 patients and was secondary to other conditions in 11. All patients presented with pain, and 16 (67%) had neurological deficits. Patients were divided into two treatment groups. Thirteen patients treated from 1949 to 1977 usually underwent limited tumor resection and external radiation therapy. The second group, 11 patients treated from 1978 to 1984, underwent more aggressive surgical resection and received combination chemotherapy as well as local radiation to the tumor bed. In the second group, there were 5 long term survivors, and only 1 patient developed metastatic disease while on therapy. Failure to obtain local control was the major cause of treatment failure. Complete surgical resection of the tumor by spondylectomy and combination chemotherapy offer the best prospect for cure of osteogenic sarcoma of the spine.