The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s.
The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s.
复制标题
中国迅速扩展的CRF01_AE流行是由1990年代引入的HIV-1病毒的多个谱系驱动的。
DOI：
10.1097/qad.0b013e328360db2d
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发表时间：
2013-07-17
期刊：
影响因子：
--
通讯作者：
Shao Y
中科院分区：
文献类型：
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作者：
Feng Y;He X;Hsi JH;Li F;Li X;Wang Q;Ruan Y;Xing H;Lam TT;Pybus OG;Takebe Y;Shao Y
对中国地区HIV-1CRF01_AE毒株的来源、传播模式和亚群流行特征进行综合分析。使用国家分子流行病学调查中确定的现有HIV-1CRF01_AE样本来生成近全长基因组(NFLG)序列。对新的和全球可用的CRF01AE NFLG序列进行系统发育和贝叶斯分子时钟分析，并结合流行病学资料分析CRF01AE在中国的传播史。我们从不同的危险人群中产生了75个新的CRF01_AE NFLG序列，覆盖了中国所有主要的CRF01_AE疫区。鉴定了CRF01_AE的7个不同的系统发育簇。群1、群2和群3在南方和西南省份的异性恋者和注射吸毒者中流行。群4和群5主要在北方主要城市的男男性接触者中发现。仅在东南部和西南部两个省的异性恋者中检测到第6和第7簇。分子时钟分析表明，所有CRF01AE集群都是在20世纪90年代从东南亚引进的，恰逢泰国艾滋病疫情高峰期，以及中国以泰国为第一目的地的公民出境游免费政策的启动。中国的HIV-1性传播流行是由CRF01AE型毒株的多个谱系引发的，而不是以前的献血员和静脉吸毒者中B‘株的单谱系流行。我们的研究强调了与肠道外传播相比，控制HIV-1性传播的难度。
We sought to comprehensively analyze the origin, transmission patterns and sub-epidemic clusters of the HIV-1 CRF01_AE strains in China. Available HIV-1 CRF01_AE samples indentified in national molecular epidemiologic surveys were used to generate near full-length genome (NFLG) sequences. The new and globally available CRF01_AE NFLG sequences were subjected to phylogenetic and Bayesian molecular clock analyses, and combined with epidemiologic data to elucidate the history of CRF01_AE transmission in China. We generated 75 new CRF01_AE NFLG sequences from various risk populations covering all major CRF01_AE epidemic regions in China. Seven distinct phylogenetic clusters of CRF01_AE were identified. Clusters 1, 2 and 3 were prevalent among heterosexuals and IDUs in southern and southwestern provinces. Clusters 4 and 5 were found primarily among MSM in major northern cities. Clusters 6 and 7 were only detected among heterosexuals in two southeast and southwest provinces. Molecular clock analysis indicated that all CRF01_AE clusters were introduced from Southeast Asia in the 1990s, coinciding with the peak of Thailand's HIV epidemic and the initiation of China's free overseas travel policy for their citizens, which started with Thailand as the first destination country. China's HIV-1 epidemic of sexual transmissions, was initiated by multilineages of CRF01_AE strains, in contrast to the mono-lineage epidemic of B′ strain in former plasma donors and IDUs. Our study underscores the difficulty in controlling HIV-1 sexual transmission compared with parenteral transmission.