Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism.
Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism.
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DOI：
10.1016/j.pedn.2004.12.009
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发表时间：
2005-04-01
期刊：
影响因子：
--
通讯作者：
Stanley, Charles A
中科院分区：
文献类型：
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作者：
Steinkrauss, Linda;Lipman, Terri H;Stanley, Charles A
患有先天性高胰岛素血症的儿童有反复发生严重低血糖的风险，可能导致癫痫发作、脑损伤和发育迟缓。为了评估这种疾病造成永久性脑损伤的频率，我们对 1980 年至 2000 年间就诊于费城儿童医院的 68 名儿童进行了电话调查。其中三分之一的人有一定程度的发育迟缓。那些在生命第一周内就诊的患者和那些医学上无反应的高胰岛素血症患者更有可能出现延误。早期识别和控制低血糖对于预防这些儿童发育迟缓至关重要。
Children with congenital hyperinsulinism are at risk for recurring, severe episodes of hypoglycemia that can cause seizures, brain damage, and developmental delay. To assess the frequency of permanent brain damage in this disorder, we carried out a telephone survey of 68 children who presented to The Children's Hospital of Philadelphia between 1980 and 2000. One third of the group had some degree of developmental delay. Those presenting in the first week of life and those with medically unresponsive hyperinsulinism were more likely to have delays. Early recognition and control of hypoglycemia are essential for preventing developmental delay in these children.