Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data.
Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data.
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DOI：
10.1186/1471-2334-12-262
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发表时间：
2012-10-18
影响因子：
3.7
通讯作者：
El-Bassel N
中科院分区：
文献类型：
--
作者：
Terlikbayeva A;Hermosilla S;Galea S;Schluger N;Yegeubayeva S;Abildayev T;Muminov T;Akiyanova F;Bartkowiak L;Zhumadilov Z;Sharman A;El-Bassel N
结核病（TB）的发生是由各种危险因素以及时间和空间分布的相互作用决定的。本研究的目的是确定哈萨克斯坦州（省）一级结核病和耐多药结核病（MDR-TB）最显着的危险因素。使用该国国家地理研究所 (NIG) 和国家结核病规划 (NTP) 提供的数据在州和国家层面进行相关性和描述性分析。报告的事件病例通知率（CNR）和患病率因州而异，因此该研究调查了哪些决定因素导致了这种区域差异，并比较了各州之间的负担。结果显示，虽然结核病 CNR 在研究期间下降，但耐多药结核病却相反增加。两个州——阿特劳斯卡亚州和曼格斯陶斯卡亚州——表现出特别显着的异常现象，结核病病例 CNR 大幅下降，而耐多药结核病病例 CNR 相对大幅增加。了解结核病和耐多药结核病病例的分布以及相关风险因素，特别是“未知风险因素”分类表明需要进行未来的研究。
Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan. Correlational and descriptive analyses were conducted at the oblast and national level using data provided by the country’s National Institute of Geography (NIG) and the National Tuberculosis Program (NTP). Reported incident case notification rates (CNRs) and prevalence vary by oblast, thus the study investigated which determinants contributed to this regional variation and compared burdens among oblasts. The results showed that while tuberculosis CNRs decreased over the study period, MDR-TB conversely increased. Two oblasts -Atyrauskaya and Mangystauskaya - presented especially significant anomalies with large decreases in TB incident CNRs coupled with comparatively large increases in MDR-TB incident CNRs. Understanding the distribution of TB and MDR-TB cases and associated risk factors, especially the “unknown risk factor” categorization points to the need for future research.
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