Exploiting Quorum Sensing Interfering Strategies in Gram-Negative Bacteria for the Enhancement of Environmental Applications.
Exploiting Quorum Sensing Interfering Strategies in Gram-Negative Bacteria for the Enhancement of Environmental Applications.
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DOI：
10.3389/fmicb.2015.01535
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发表时间：
2015
影响因子：
5.2
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Zhang W;Li C
群体感应（Quorum sensing，QS）是一种广泛存在于细胞间的通讯方式，它通过产生、分泌和检测小分子可扩散的自诱导物，如酰基高丝氨酸内酯（acyl-homoserine lactones，AHLs）、自诱导寡肽（auto-inducing oligo-peptides，AIPs）和自诱导物2（autoinducer 2）来协调细菌的生理过程和协同活动。本文综述了革兰氏阴性菌QS自诱导物在污水处理系统中的作用。基于过去10年来的研究，讨论了QS参与生物膜和好氧颗粒的形成以及微生物群落和降解/转化途径的变化。特别是，QS途径在水产养殖中细菌感染和疾病预防中的作用得到了解决。QS自身诱导物调节途径的干扰被认为是各种环境相关问题的潜在治疗方法。这一审查预计将作为一个垫脚石，进一步研究和发展战略的基础上调解的QS调节途径，以提高应用在废水处理系统和水产养殖。
Quorum sensing (QS) is a widespread intercellular form of communication to coordinate physiological processes and cooperative activities of bacteria at the population level, and it depends on the production, secretion, and detection of small diffusible autoinducers, such as acyl-homoserine lactones (AHLs), auto-inducing oligo-peptides (AIPs) and autoinducer 2. In this review, the function of QS autoinducers of gram-negative bacteria in different aspects of wastewater treatment systems is examined. Based on research primarily performed over the past 10 years, QS involvement in the formation of biofilm and aerobic granules and changes of the microbial community and degradation/transformation pathways is discussed. In particular, the QS pathway in the role of bacterial infections and disease prevention in aquaculture is addressed. Interference of QS autoinducer-regulated pathways is considered potential treatment for a variety of environmentally related problems. This review is expected to serve as a stepping stone for further study and development strategies based on the mediation of QS-regulated pathways to enhance applications in both wastewater treatment systems and aquaculture.