The nucleolar detention pathway A cellular strategy for regulating molecular networks
The nucleolar detention pathway A cellular strategy for regulating molecular networks
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DOI：
10.4161/cc.20140
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发表时间：
2012-06-01
期刊：
影响因子：
4.3
通讯作者：
Lee, Stephen
中科院分区：
文献类型：
--
作者：
Audas, Timothy E.;Jacob, Mathieu D.;Lee, Stephen
分子动力学确保蛋白质和其他因子以及时有效的方式到达其作用部位。这对于分子复合物的形成至关重要，因为它们需要不断变化的特定相互作用框架来促进自组装模型。因此，任何关键组分的缺乏或可用性降低将显著损害复合物的形成并破坏所有下游分子网络。最近，我们确定了一个调节机制，通过诱导表达的一个新的家庭长的非编码RNA调节蛋白质的流动性。为了响应不同的环境刺激，核仁滞留途径（NoDP）捕获并固定核仁内的重要细胞因子，使其远离效应分子。大量推定的NoDP靶点，包括DNA（胞嘧啶-5）-甲基转移酶1（DNMT 1）和DNA聚合酶的δ催化亚基（POLD 1），表明这可能是一种常见且重要的调控机制。在这里，我们讨论了这种新的翻译后策略调节分子网络的影响。
Molecular dynamics ensure that proteins and other factors reach their site of action in a timely and efficient manner. This is essential to the formation of molecular complexes, as they require an ever-changing framework of specific interactions to facilitate a model of self-assembly. Therefore, the absence or reduced availability of any key component would significantly impair complex formation and disrupt all downstream molecular networks. Recently, we identified a regulatory mechanism that modulates protein mobility through the inducible expression of a novel family of long noncoding RNA. In response to diverse environmental stimuli, the nucleolar detention pathway (NoDP) captures and immobilizes essential cellular factors within the nucleolus away from their effector molecules. The vast array of putative NoDP targets, including DNA (cytosine-5)-methyltransferase 1 (DNMT1) and the delta catalytic subunit of DNA polymerase (POLD1), suggests that this may be a common and significant regulatory mechanism. Here, we discuss the implications of this new posttranslational strategy for regulating molecular networks.