RAPIDLY REVERSIBLE ALTERATIONS OF PULMONARY EPITHELIAL PERMEABILITY INDUCED BY SMOKING
RAPIDLY REVERSIBLE ALTERATIONS OF PULMONARY EPITHELIAL PERMEABILITY INDUCED BY SMOKING
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DOI：
10.1378/chest.83.1.6
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发表时间：
1983-01-01
期刊：
影响因子：
9.6
通讯作者：
REID, E
中科院分区：
文献类型：
--
作者：
MASON, GR;USZLER, JM;REID, E
使用放射性气溶胶程序使用99 mTc-DTPA（二乙烯三胺五乙酸酯）来评估吸烟者和非吸烟者的肺上皮的通透性。无明显气道阻塞的吸烟者肺中该指标的平均清除率超过正常[人类]受试者的平均清除率> 5倍。在所有肺区域均观察到该异常。在戒烟后的一周内，99 mTc-DTPA清除率迅速下降。吸烟导致肺上皮通透性迅速可逆性增加。
A radioaerosol procedure using 99mTc-DTPA (diethylenetriamine pentaacetate) was used to evaluate the permeability of the pulmonary epithelium in smokers and nonsmokers. The average clearance of this indicator from the lungs of smokers wihtout significant airway obstruction exceeded that found in normal [human] subjects by an average factor of > 5. This abnormality was observed throughout all lung regions. 99mTc-DTPA clearance decreased rapidly during the week after smoking was discontinued. Smoking results in a rapidly reversible increase in pulmonary epithelial permeability.