REGULATION OF HUMORAL IMMUNITY IN THE PIGLET BY IMMUNOGLOBULINS OF MATERNAL ORIGIN
REGULATION OF HUMORAL IMMUNITY IN THE PIGLET BY IMMUNOGLOBULINS OF MATERNAL ORIGIN
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DOI：
10.1016/s0034-5288(18)32494-9
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发表时间：
1981-01-01
影响因子：
2.4
通讯作者：
BUTLER, JE
中科院分区：
文献类型：
--
作者：
KLOBASA, F;WERHAHN, E;BUTLER, JE
通过监测1 ~ 8周龄仔猪血清中IgG、IgA和IgM的吸收和合成，研究了母体IgG、IgA和IgM的吸收和合成。A组（94只动物）与母猪一起饲养。将仔猪亚组撤回0-24 h，然后将其送回母猪。组B（45只动物）在自动饲喂装置中以牛初乳和牛奶饲养，并在出生后第1天给予动物不同量的纯化猪IgG。记录了在自然环境中无法存活的自然饲养仔猪（41头）。A组血清IG水平在哺乳开始后12 h达到峰值。然后血清水平下降，IgG、伊加和IgM的半衰期分别为10、2和3天，血清最低值分别出现在第5、3和2周。IG的吸收与仔猪从母猪体内取出的时间长短直接相关，这种减少是由于这段时间内初乳中IG水平的降低所致。所有3种同种型的合成幅度与吸收量呈负相关。在剥夺初乳的仔猪，只有IgM抗体存在于出生时的血清中，但所有3个存在1周。合成的IG的量与施用的纯化猪IgG的量成反比。给予3.5 g猪IgG对所有3种同种型的合成具有与在自然饲养动物中观察到的相同的作用。在初乳剥夺仔猪中，血清水平在2周（IgM）和5-6周（IgG和伊加）达到峰值;自然饲养或给予IgG的仔猪分别在6、8和8周达到峰值。在自动饲喂装置中饲养的仔猪比允许随意吮吸的仔猪表现出更一致的吸收模式。该组中几乎所有未能存活的41头小猪在哺乳后的前12小时内吸收的IG仅为其年龄匹配的存活对照组的10-50%。本文还讨论了母体初乳和/或IgG对IG合成的可能调节机制。
Absorption and synthesis of maternal IgG, IgA and IgM were studied by monitoring piglet serum levels for the 1st 8 wk of life. Group A (94 animals) was maintained with the sow. Subgroups of piglets were withdrawn for 0-24 h before returning them to the sow. Group B (45 animals) was reared in an automatic feeding device on bovine colostrum and milk and animals were given various quantities of purified swine IgG during the 1st day of life. Naturally reared piglets (41) that failed to survive in their natural environment were recorded. In group A peak serum Ig levels were reached 12 h after beginning of suckling. Serum levels then declined with halflives of 10, 2 and 3 days for IgG, IgA and IgM, respectively, with minimum serum values occurring on week 5, 3 and 2 respectively. Absorption of Ig was directly related to the length of time the piglets were removed from the sow, the decrease being caused by the decrease of Ig levels in colostrum during this time. The magnitude of synthesis of all 3 isotypes was inversely related to the amount absorbed. In piglets deprived of colostrum, only IgM was present in serum at birth but all 3 were present by 1 wk. The amount of Ig synthesized was inversely proportional to the amount of purified swine IgG administered. Administration of 3.5 g of swine IgG had the same effect on synthesis of all 3 isotypes as was observed in the naturally reared animals. In the colostrum-deprived piglets, serum levels peaked at 2 wk (IgM) and 5-6 wk (IgG and IgA); those reared naturally or given IgG peaked at 6, 8 and 8 wk respectively. Piglets reared in the automatic feeding device showed more consistent patterns of absorption than those allowed to suck ad libitum. Nearly all of the 41 piglets in the group which failed to survive absorbed only 10-50% as much Ig in the first 12 h after suckling as their age-matched surviving controls. The possible mechanisms of regulation by maternal colostrum and, or IgG on Ig synthesis are discussed.