Morphometric abnormalities and hyperanxiety in genetically epileptic rats: A model of psychiatric comorbidity?
Morphometric abnormalities and hyperanxiety in genetically epileptic rats: A model of psychiatric comorbidity?
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DOI：
10.1016/j.neuroimage.2008.12.019
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发表时间：
2009-04-01
期刊：
影响因子：
5.7
通讯作者：
Jones, Nigel C.
中科院分区：
文献类型：
--
作者：
Bouilleret, Viviane;Hogan, R. Edward;Jones, Nigel C.
背景：对合并情感障碍的癫痫患者的影像研究表明，与精神疾病有关的边缘脑区的形态计量学改变。来自斯特拉斯堡的遗传性缺失性癫痫大鼠(GAERS)是为其癫痫表型而培育的，也表现出高焦虑样行为，表明共同的因果关系。在这里，我们使用体积测量和大变形高维映射(HDM-LD)来检查这种大鼠品系是否存在相关的脑形态变化，HDM-LD是一种最近被验证的工具，可以生成准确的海马区三维表面图像。方法：对成年雌性GAERS(n=12)和非癫痫对照组(n=11)进行体积MRI和焦虑的Open field测试。用感兴趣区分析的方法测量大脑皮质、海马体、杏仁核、丘脑、下丘脑和侧脑室的体积，并对两个品系的总体积进行比较。结果：GERS增加了杏仁核(右侧：P=0.003；左侧P
Background: Imaging studies of epilepsy patients with comorbid affective disturbance demonstrate morphometric changes in limbic brain regions implicated in psychiatric disease. Genetic Absence Epilepsy Rats from Strasbourg (GAERS), specifically bred for their epilepsy phenotype, also exhibit elevated anxiety-like behaviors suggesting a common causality. Here we examined whether relevant cerebral morphological alterations exist in this rat strain using volumetric measurements and large deformation high dimensional mapping (HDM-LD), a tool recently validated to produce accurate three-dimensional surface representations of the hippocampus.Methods: Volumetric MRI and the Open Field test of anxiety were performed in adult female GAERS (n=12) and Non-Epileptic Controls (NEC; n=11). The volumes of selected brain regions, including cortex, hippocampus, amygdala, thalamus, hypothalamus and lateral ventricles, were measured using Region-Of-Interest analysis from the MRI data and total volumes compared between the two strains.Results: GAERS had increased amygdala (right: p=0.003; left p