A glimpse at the aging eye.
A glimpse at the aging eye.
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DOI：
10.1038/npjamd.2016.3
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发表时间：
2016
影响因子：
5
通讯作者：
Apte RS
中科院分区：
文献类型：
--
作者：
Lin JB;Tsubota K;Apte RS
广泛的研究表明，机体衰老与许多器官的组织功能障碍有关。眼睛也不例外。在健康条件下，眼睛的设计就像一台先进的相机，其核心作用是将来自外部世界的光转化为连贯的神经信号，该信号可以传输到大脑处理成精确的视觉图像。这个复杂的过程需要精确维护的机器。在眼睛的前部，角膜和晶状体的透明度对于允许光子通过眼睛的光敏感部分至关重要。同样，位于眼睛后部的视网膜的高度组织结构对于有效的信号转导和高效的信号传输是必不可少的。衰老以多种方式影响眼部结构，这些后遗症已被明确定义为不同的临床实体。在许多情况下，衰老会导致眼组织功能障碍和疾病。尽管如此，尽管有明确的证据表明与年龄相关的视力障碍具有显着的心理社会后果，但目前针对许多此类疾病的治疗模式还不够。此外，减缓或逆转与年龄相关的眼功能恶化的策略仍处于起步阶段。本综述重点关注衰老眼睛的细胞和分子病理生理学。最终，我们希望对衰老眼睛的深入了解能够指导针对细胞衰老和疾病的靶向治疗。
Extensive investigations have demonstrated that organismal aging is associated with tissue dysfunction in many organs. The eye is no exception to this rule. Under healthy conditions, the eye is designed like an advanced camera with the central role of translating light from the external world into a coherent neural signal that can be transmitted to the brain for processing into a precise visual image. This complex process requires precisely maintained machinery. At the front of the eye, the transparency of both the cornea and the lens are crucial to allow passage of photons to the light-sensitive portion of the eye. Similarly, the highly organized structure of the retina located at the back of the eye is indispensable to allow for effective signal transduction and efficient signal transmission. Aging affects ocular structures in various ways, and these sequelae have been well defined as distinct clinical entities. In many instances, aging leads to ocular tissue dysfunction and disease. Nonetheless, despite clear evidence that age-associated visual impairment has significant psychosocial consequences, current treatment paradigms for many of these conditions are inadequate. In addition, strategies to decelerate or reverse age-associated deterioration in ocular function are still in their infancy. This review focuses on the cellular and molecular pathophysiology of the aging eye. Ultimately, we hope that a refined understanding of the aging eye can guide targeted therapies against cellular aging and disease.