Epidemiology of interstitial cystitis
Epidemiology of interstitial cystitis
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DOI：
10.1016/s0090-4295(99)80327-6
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发表时间：
1997-05-01
期刊：
影响因子：
2.1
通讯作者：
Nyberg, L
中科院分区：
文献类型：
--
作者：
Jones, CA;Nyberg, L
目标。讨论目前已知的间质性膀胱炎 (IC) 人群患病率和 IC 患者的人口特征。方法。描述了 IC 诊断标准随时间的变化。对已发表的 3 项 IC 人群患病率研究进行了回顾。引用了 IC 研究设计中重要的流行病学问题。结果。 IC 是一种慢性排尿症状的疾病。关于病因、危险因素或受影响人数的可靠信息非常少。不同研究者用于诊断 IC 的标准各不相同。 1988 年，发布了 IC 病例定义的研究标准，适用于参加美国国立卫生研究院资助的研究的 IC 患者。目前已发表三项关于 IC 人群患病率的研究。每项研究都使用不同的标准来定义 IC 病例，并且没有一项研究使用 NIH 研究标准来定义病例。 IC 患病率估计差异很大，从 1975 年芬兰报告的 10 例/100,000 例（基于医院记录审查），到 1987 年美国的 30/100,000 例（基于委员会认证泌尿科医生的邮寄调查），再到 1989 年美国的 510 例/100,000 例（基于参与者自我报告） 1989 年全国健康访谈调查）。目前尚不清楚这些估计值在多大程度上代表了患病率的真实差异，而不是反映了用于定义 IC 病例的不同方法。一些研究人员报告了他们诊所跟踪的 IC 患者的人口统计特征。所有针对成年人的研究都显示女性明显占主导地位，据报道症状通常在中年出现。患者从出现症状到确诊可能会延迟数年。据报道，IC 症状的自然病程是亚急性发作，严重程度迅速达到峰值，然后是慢性症状相对稳定的平台期。然而，许多患者的疾病症状确实有所缓解和加剧。结论。很少有 IC 疗法使用严格的流行病学方法进行评估。许多问题仍有待解答。新的 IC 研究应在研究设计阶段包括流行病学咨询。 (C) 1997 年，爱思唯尔科学公司。
Objectives. To discuss what is currently known about the population prevalence of interstitial cystitis (IC) and demographic characteristics of IC patients.Methods. Changes over time in the criteria for diagnosis of IC are described. The 3 published studies of the population prevalence of IC are reviewed. Epidemiologic issues important in the design of studies of IC are cited.Results. IC is a disease of chronic voiding symptoms. There is very little reliable information published on the etiology, risk factors, or number of persons affected. The criteria used for diagnosis of IC by different investigators have been variable. In 1988, research criteria for a case definition of IC were published, to be applied for IC patients enrolled in National Institutes of Health-funded studies. Three published studies of the population prevalence of IC are available. Each study used different criteria for defining a case of IC, and none used the NIH research criteria to define a case. Prevalence estimates for IC vary significantly, from 10 cases/100,000 reported in Finland in 1975, (based on hospital record review), to 30/100,000 in the United States in 1987, (based on a mailed survey of board certified urologists), to 510 cases/100,000 in the United States in 1989, (based on participant self-report in the 1989 National Health Interview Survey). It is unclear the extent to which these estimates represent true differences in prevalence, rather than reflect the different methods used to define an IC case. Several investigators have reported demographic characteristics of the IC patients followed in their clinics. All studies of adults show a marked female predominance, with reported onset of symptoms generally in the middle years of life. Patients may experience a delay of years from the onset of symptoms to the time of definitive diagnosis. The natural history of symptoms of IC has been reported to be that of a subacute onset with a rapid peak in severity, and then a relatively constant plateau of chronic symptoms thereafter. However, many patients do experience remissions and flares in their disease symptoms.Conclusions. Few therapies for IC have been evaluated using rigorous epidemiologic methods. Many questions remain to be answered. New studies of IC should include epidemiologic consultation at the stage of study design. (C) 1997 by Elsevier Science Inc.