Raised serum alkaline phosphatase and aspartate transaminase levels in two rheumatoid patients treated with sulphasalazine.
Raised serum alkaline phosphatase and aspartate transaminase levels in two rheumatoid patients treated with sulphasalazine.
复制标题
两名接受柳氮磺胺吡啶治疗的类风湿患者的血清碱性磷酸酶和天冬氨酸转氨酶水平升高。
DOI：
10.1136/ard.44.11.798
复制
发表时间：
1985
影响因子：
27.4
通讯作者：
P. Bacon
中科院分区：
文献类型：
--
作者：
M. Farr;D. Symmons;P. Bacon
肝毒性是柳氮磺胺吡啶治疗溃疡性结肠炎的罕见并发症。这份报告描述了两个类风湿患者，他们在开始柳氮磺胺吡啶治疗关节炎后不久血清肝酶水平升高。在这两种情况下，停药后血清酶水平恢复正常。类风湿性关节炎（RA）患者在服用柳氮磺胺吡啶时血清肝酶水平升高，应考虑药物诱导的肝毒性。
Hepatotoxicity is a rare complication of sulphasalazine therapy in ulcerative colitis. This report describes two rheumatoid patients in whom raised serum levels of liver enzymes occurred soon after starting sulphasalazine treatment for their arthritis. In both cases the serum enzyme levels returned to normal after stopping the drug. Drug-induced hepatotoxicity should be considered in patients with rheumatoid arthritis (RA) who develop raised serum levels of liver enzymes while taking sulphasalazine.